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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2onp NAD Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.127
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.091
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.065
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.040
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.040
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 1.015
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.999
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.997
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.984
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.982
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.904
4pt0 NADAldehyde dehydrogenase / 0.900
4pxl NADAldehyde dehydrogenase3 / 0.898
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.891
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.884
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.867
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.865
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.863
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.811
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.805
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.804
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.794
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.785
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.783
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.780
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.772
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.770
3iwj NADAminoaldehyde dehydrogenase / 0.763
3b4w NADAldehyde dehydrogenase family protein / 0.759
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.759
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.753
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.750
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.748
4i3w NADAldehyde dehydrogenase (NAD+) / 0.747
4f3x NADPutative aldehyde dehydrogenase / 0.744
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.743
4i8p NADAminoaldehyde dehydrogenase 1 / 0.743
5dib NADBetaine-aldehyde dehydrogenase / 0.742
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.741
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.741
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.740
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.740
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.736
4i9b NADPutative betaine aldehyde dehyrogenase / 0.734
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.731
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.726
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.721
1bi9 NADRetinal dehydrogenase 2 / 0.718
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.716
4i8q NADPutative betaine aldehyde dehyrogenase / 0.716
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.714
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.714
4pz2 NADAldehyde dehydrogenase 2-6 / 0.712
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.709
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.707
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.707
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.706
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.704
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.702
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.702
5eyu NADBetaine-aldehyde dehydrogenase / 0.700
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.695
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.691
2jg7 NADAntiquitin / 0.687
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.687
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.686
4pt3 NDPAldehyde dehydrogenase / 0.684
5ez4 NADBetaine-aldehyde dehydrogenase / 0.679
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.676
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.672
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.670
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.668
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.666
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.665
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.663
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.653
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.653
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.651