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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2olc ADP Methylthioribose kinase 2.7.1.100

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2olc ADPMethylthioribose kinase 2.7.1.100 0.924
2pul ACPMethylthioribose kinase 2.7.1.100 0.909
2pui ADPMethylthioribose kinase 2.7.1.100 0.899
2pun ACPMethylthioribose kinase 2.7.1.100 0.869
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.791
2pyw ADPMethylthioribose kinase 2.7.1.100 0.785
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.784
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.783
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.781
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.775
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.774
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.773
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.773
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.772
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.772
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.769
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.768
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.766
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.766
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.763
2pup ADPMethylthioribose kinase 2.7.1.100 0.763
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.762
3c4z ADPRhodopsin kinase / 0.760
3c50 ADPRhodopsin kinase / 0.758
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.758
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.757
3t8o ATPRhodopsin kinase / 0.755
4qny ANPMitogen activated protein kinase, putative / 0.754
3qc9 ADPRhodopsin kinase / 0.753
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.752
4gyi ADPUncharacterized protein / 0.752
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.751
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.750
4utd ACPAurora kinase A 2.7.11.1 0.750
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.749
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.747
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.745
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.745
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.744
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.744
4xlv ACPInsulin receptor 2.7.10.1 0.744
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.743
3bu5 ATPInsulin receptor 2.7.10.1 0.743
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.743
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.741
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.740
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.740
5dt3 ATPAurora kinase A 2.7.11.1 0.740
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.738
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.738
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.737
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.737
5dos ATPAurora kinase A 2.7.11.1 0.737
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.735
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.733
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.732
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.732
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.731
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.730
4ceg ADPAurora kinase A 2.7.11.1 0.730
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.729
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.728
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.728
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.726
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.722
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
5dn3 ATPAurora kinase A 2.7.11.1 0.722
5dt4 ATPAurora kinase A 2.7.11.1 0.722
1mq4 ADPAurora kinase A 2.7.11.1 0.721
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.721
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.720
3c4w ATPRhodopsin kinase / 0.720
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.719
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.719
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.717
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.716
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.716
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.716
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.716
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.715
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.715
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.714
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.714
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.714
2dwb ANPAurora kinase A 2.7.11.1 0.713
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
5eg3 ACPFibroblast growth factor receptor 2 / 0.713
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.712
1ol5 ADPAurora kinase A 2.7.11.1 0.711
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
1ol6 ATPAurora kinase A 2.7.11.1 0.710
5drd ATPAurora kinase A 2.7.11.1 0.710
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.709
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.709
4ysj ADPCalmodulin-like domain protein kinase / 0.708
5dr2 ATPAurora kinase A 2.7.11.1 0.708
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.707
4q5h ANPProtein kinase OspG 2.7 0.707
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
1u54 ACPActivated CDC42 kinase 1 / 0.705
4dee ADPAurora kinase A 2.7.11.1 0.705
5dnr ATPAurora kinase A 2.7.11.1 0.705
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.704
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.703
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.703
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.703
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.703
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.703
3nie ANPMitogen-activated protein kinase / 0.702
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.701
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.701
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.699
1cm8 ANPMitogen-activated protein kinase 12 / 0.698
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.698
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.698
4o4e ATPKinase / 0.698
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.698
5iqh GNPBifunctional AAC/APH 2.3.1 0.698
4o4f ATPKinase / 0.697
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.696
2pz5 ACPFibroblast growth factor receptor 2 / 0.695
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.694
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.693
2yaa ATPDeath-associated protein kinase 2 / 0.693
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.693
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.691
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.690
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
3q5i ANPProtein kinase, putative / 0.689
5iqb GNPBifunctional AAC/APH 2.3.1 0.689
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.687
3g8c ADPBiotin carboxylase 6.3.4.14 0.687
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.687
1ol7 ADPAurora kinase A 2.7.11.1 0.686
5byl GCPBifunctional AAC/APH 2.3.1 0.686
4ork GDPBifunctional AAC/APH 2.3.1 0.685
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.684
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
1i44 ACPInsulin receptor 2.7.10.1 0.683
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.683
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.683
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.683
2vqd AP2Biotin carboxylase 6.3.4.14 0.682
4o4d ATPKinase / 0.681
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.680
4zgn ATPCell division cycle protein 123 / 0.680
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.679
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.679
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.679
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.678
4bn1 ADPAurora kinase A 2.7.11.1 0.676
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.675
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.675
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.674
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.674
4c3r ACPAurora kinase A 2.7.11.1 0.674
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.674
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.673
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.673
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.672
3oro AGSSerine/threonine protein kinase / 0.671
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.671
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.671
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.671
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.669
2pzp ACPFibroblast growth factor receptor 2 / 0.668
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.668
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.668
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.667
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.667
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.666
1ir3 ANPInsulin receptor 2.7.10.1 0.665
5l8l ADPAurora kinase A 2.7.11.1 0.665
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.664
3a8w ATPProtein kinase C iota type 2.7.11.13 0.664
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.663
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.663
1jst ATPCyclin-dependent kinase 2 2.7.11.22 0.662
1px2 ATPSynapsin-1 / 0.662
2zdg ADPD-alanine--D-alanine ligase / 0.662
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.662
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.661
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.661
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.660
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.660
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.660
5l8k ADPAurora kinase A 2.7.11.1 0.660
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.658
3ibq ATPPyridoxal kinase / 0.658
5iqi GNPBifunctional AAC/APH 2.3.1 0.658
2py3 ACPFibroblast growth factor receptor 2 / 0.657
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.657
3hyo ADPPyridoxal kinase / 0.657
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.657
4dt8 ADNAPH(2'')-Id / 0.657
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.656
4ffm ADPUncharacterized protein / 0.656
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.655
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.655
2pml ANPUncharacterized protein / 0.655
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.655
4j98 ACPFibroblast growth factor receptor 2 / 0.655
5ckw ANPUncharacterized protein / 0.655
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.654
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.654
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.654
2fsn ADPArchaeal actin homolog / 0.653
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.653
3a8t ATPAdenylate isopentenyltransferase / 0.653
3r5f ATPD-alanine--D-alanine ligase / 0.653
3tdw GDPGentamicin resistance protein / 0.653
3tw6 ADPPyruvate carboxylase / 0.653
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.653
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1m0w ANPGlutathione synthetase 6.3.2.3 0.652
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.652
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.652
4ffl ADPUncharacterized protein / 0.652
4wzy ATPMaltokinase 2.7.1.175 0.652
3wo1 ADPAlanine--anticapsin ligase / 0.651
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.651
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.650
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.650