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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2oiq STI Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.156
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.050
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.950
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.869
2pl0 STITyrosine-protein kinase Lck 2.7.10.2 0.857
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.829
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.759
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.754
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.751
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.740
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.728
3bv2 P38Mitogen-activated protein kinase 14 / 0.709
3gfe P37Mitogen-activated protein kinase 14 / 0.697
3bv3 P39Mitogen-activated protein kinase 14 / 0.695
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.692
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.680
3ocg OCGMitogen-activated protein kinase 14 / 0.679
3lfa 1N1Mitogen-activated protein kinase 14 / 0.669
3bx5 304Mitogen-activated protein kinase 14 / 0.668
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.667
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.660
1wbs LI2Mitogen-activated protein kinase 14 / 0.656
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.655
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.651