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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2oh4 GIG Vascular endothelial growth factor receptor 2 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 1.336
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.883
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.878
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.823
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.785
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.779
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.768
3gi3 B10Mitogen-activated protein kinase 14 / 0.752
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.745
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.741
3el7 PD3Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.719
3hv3 R49Mitogen-activated protein kinase 14 / 0.712
4o2z 046Mitogen-activated protein kinase / 0.697
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.694
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.694
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.689
2zjf BSUEpoxide hydrolase B / 0.684
4ja8 1K9Isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.673
1w82 L10Mitogen-activated protein kinase 14 / 0.671
3b8r 887Vascular endothelial growth factor receptor 2 2.7.10.1 0.671
3gcs BAXMitogen-activated protein kinase 14 / 0.670
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.668
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.665
2yis YISMitogen-activated protein kinase 14 / 0.663
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.662
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.660
3lfe Z84Mitogen-activated protein kinase 14 / 0.658
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.657
4fny I3KALK tyrosine kinase receptor 2.7.10.1 0.655
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.654
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.654
3hv4 L51Mitogen-activated protein kinase 14 / 0.653
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.650
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.650
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.650