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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2np8 CC3 Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2np8 CC3Aurora kinase A 2.7.11.1 0.995
3uo5 0BXAurora kinase A 2.7.11.1 0.784
4dea NHIAurora kinase A 2.7.11.1 0.781
5dt0 SKEAurora kinase A 2.7.11.1 0.684
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.677
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.665
3ztx ZTXAurora kinase B-A 2.7.11.1 0.662
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.661
5dr6 SKEAurora kinase A 2.7.11.1 0.661
3efw AK8Aurora kinase A 2.7.11.1 0.659
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.658
4gih 0X5Non-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.658
4fsy HK7Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2x6d X6DAurora kinase A 2.7.11.1 0.652