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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jkq VG8 Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2jkq VG8Focal adhesion kinase 1 2.7.10.2 1.078
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.848
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.761
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.739
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.726
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.696
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.692
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.690
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.686
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.686
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.685
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.684
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.683
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.682
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.680
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.675
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.672
4a4o 664Serine/threonine-protein kinase PLK1 2.7.11.21 0.668
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.668
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.667
2vgp AD6Aurora kinase B-A 2.7.11.1 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4g3f 0WBMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.659
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.653
1oec AA2Fibroblast growth factor receptor 2 / 0.652
4b0g VEKAurora kinase A 2.7.11.1 0.651
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.650