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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jib TPP Oxalyl-CoA decarboxylase 4.1.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 1.222
2ji6 TPWOxalyl-CoA decarboxylase 4.1.1.8 1.157
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 1.148
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 1.124
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 1.050
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.742
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.735
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.733
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.726
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.725
4cok TPPPyruvate decarboxylase / 0.724
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.720
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.717
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.713
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.711
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.711
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.711
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.709
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.704
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.703
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.699
1gwn GTPRho-related GTP-binding protein RhoE / 0.698
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.697
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.694
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.694
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.692
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.692
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.692
5la6 GTPTubulin alpha-1B chain / 0.686
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.685
3rim TPPTransketolase 2.2.1.1 0.685
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.684
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.681
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.680
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.679
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.679
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.679
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.678
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.678
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.676
4fvq ATPTyrosine-protein kinase JAK2 / 0.675
3ahi HTLProbable phosphoketolase / 0.674
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.673
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.672
3m0e ATPTranscriptional regulator (NtrC family) / 0.672
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.671
1pow TPPPyruvate oxidase 1.2.3.3 0.671
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.670
5dac AGSUncharacterized protein / 0.670
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.670
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.669
5itz GTPTubulin alpha-1B chain / 0.669
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.667
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.666
3iae D7KBenzaldehyde lyase / 0.666
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.665
1t91 GTPRas-related protein Rab-7a / 0.663
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.660
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.660
4c0b ATPmRNA cleavage and polyadenylation factor CLP1 / 0.660
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.660
3vhx GTPADP-ribosylation factor 6 / 0.659
5jqg GTPTubulin alpha-1B chain / 0.659
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.658
1m7b GTPRho-related GTP-binding protein RhoE / 0.656
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.656
4nu0 AP5Adenylate kinase / 0.655
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.655
2c3y HTLPyruvate synthase / 0.653
3dl0 AP5Adenylate kinase / 0.653
3tgp GNPGTPase HRas / 0.653
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.653
4w5j AP5Adenylate kinase / 0.653
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.652
5ahk TPPAcetolactate synthase II, large subunit / 0.652
2eu8 AP5Adenylate kinase / 0.651
2oo7 AP5Adenylate kinase / 0.651
3au2 DGTDNA polymerase beta family (X family) / 0.650
4qpz TPPBenzaldehyde lyase / 0.650