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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jhf NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.243
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.239
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.220
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.202
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.189
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.187
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.171
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.171
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.170
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.169
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.160
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.156
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.149
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.141
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.140
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.137
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.136
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.131
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.129
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.128
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.125
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.121
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.110
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.103
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.089
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.084
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.079
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.073
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.056
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.040
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.019
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.943
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.935
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.910
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.908
3jv7 NADSecondary alcohol dehydrogenase / 0.876
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.868
3wle NAD(R)-specific carbonyl reductase / 0.868
4oaq NDPR-specific carbonyl reductase / 0.854
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.852
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.847
3two NDPMannitol dehydrogenase / 0.840
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.837
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.836
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.833
1yqd NAPSinapyl alcohol dehydrogenase / 0.822
4l0q NADAlcohol dehydrogenase class-3 / 0.819
1uxj NADMalate dehydrogenase / 0.814
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.810
4c4o NADSADH / 0.808
4jji NADAlcohol dehydrogenase class-3 / 0.808
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.796
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.786
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.782
2xaa NADSecondary alcohol dehydrogenase / 0.779
4cpd NADAlcohol dehydrogenase / 0.778
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.776
1uxk NADMalate dehydrogenase / 0.774
1u7h NADPutative ornithine cyclodeaminase / 0.769
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.767
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.764
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.762
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.760
4rqu NADAlcohol dehydrogenase class-P / 0.756
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.754
1x7d NADPutative ornithine cyclodeaminase / 0.752
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.750
3uko NADAlcohol dehydrogenase class-3 / 0.747
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.745
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.735
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.731
1yqx NAPSinapyl alcohol dehydrogenase / 0.729
4gl4 NAIAlcohol dehydrogenase class-3 / 0.728
2x0i NAIMalate dehydrogenase / 0.724
2dph NADFormaldehyde dismutase / 0.723
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.721
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.721
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.718
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.717
5a1t NAIL-lactate dehydrogenase / 0.716
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.707
1pzh NADLactate dehydrogenase / 0.705
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.705
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.703
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.701
2vhx NADAlanine dehydrogenase 1.4.1.1 0.699
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.699
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.699
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.697
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.697
4uun NAIL-lactate dehydrogenase / 0.697
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.694
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.689
1guy NADMalate dehydrogenase / 0.687
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.685
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.684
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.683
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.682
2cdc NAPGlucose 1-dehydrogenase / 0.682
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.681
2cda NAPGlucose 1-dehydrogenase / 0.680
4ejm NAPPutative zinc-binding dehydrogenase / 0.680
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.677
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.675
1o6z NADMalate dehydrogenase / 0.672
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.672
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.669
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.668
4i1i NADMalate dehydrogenase / 0.668
4j4b NAIUncharacterized protein / 0.668
1obb NADAlpha-glucosidase 3.2.1.20 0.666
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.666
2vwh NAPGlucose 1-dehydrogenase / 0.666
3wfj NAD2-dehydropantoate 2-reductase / 0.664
4j43 NADUncharacterized protein / 0.664
3x2f NAIAdenosylhomocysteinase / 0.663
2voj NADAlanine dehydrogenase 1.4.1.1 0.661
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.660
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.659
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.659
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.658
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.657
1b8v NADMalate dehydrogenase / 0.656
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.656
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.656
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.656
1pjc NADAlanine dehydrogenase / 0.655
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.655
1c1d NAIPhenylalanine dehydrogenase / 0.653
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.653
2vna NAPProstaglandin reductase 2 1.3.1.48 0.652
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.652
1ie3 NADMalate dehydrogenase / 0.651
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.651