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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j6x FMN Lactate oxidase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j6x FMNLactate oxidase / 1.348
4yl2 FMNLactate oxidase / 1.292
2nli FMNLactate oxidase / 1.255
2zfa FMNLactate oxidase / 1.222
4rje FNRLactate oxidase / 1.213
5ebu FMNLactate oxidase / 1.208
2du2 FMNLactate oxidase / 1.072
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.973
2e77 FMNLactate oxidase / 0.930
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.907
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.896
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.886
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.853
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.843
3n14 FMNXenobiotic reductase / 0.830
3l67 FMNXenobiotic reductase / 0.828
3l5l FMNXenobiotic reductase / 0.817
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.815
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.815
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.814
4uth FMNXenobiotic reductase / 0.813
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.811
4utl FNRXenobiotic reductase / 0.808
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.807
3n19 FNRXenobiotic reductase / 0.805
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.797
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.796
4tmc FMNOld yellow enzyme / 0.796
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.793
4e2d FMNDehydrogenase / 0.782
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.782
2h8x FMNXenA / 0.781
4utm FNRXenobiotic reductase / 0.780
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.779
2oz0 FMNCytochrome b2, mitochondrial 1.1.2.3 0.778
4tmb FMNOld yellow enzyme / 0.777
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.774
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.772
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.766
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.765
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.764
1gwj FMNMorphinone reductase / 0.763
1z48 FMNNADPH dehydrogenase / 0.760
3tjl FMNNADPH dehydrogenase / 0.760
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.758
1z44 FMNNADPH dehydrogenase / 0.756
3hf3 FMNChromate reductase / 0.755
1vhn FMNtRNA-dihydrouridine synthase / 0.754
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.751
1z41 FMNNADPH dehydrogenase / 0.750
3gka FMNN-ethylmaleimide reductase / 0.748
3gr8 FMNNADPH dehydrogenase / 0.747
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.746
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.746
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.744
3p62 FMNPentaerythritol tetranitrate reductase / 0.744
4yco FMNtRNA-dihydrouridine(16) synthase / 0.744
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.743
3p84 FMNPentaerythritol tetranitrate reductase / 0.742
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.741
3p74 FMNPentaerythritol tetranitrate reductase / 0.740
4m5p FMNNADPH dehydrogenase / 0.739
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.737
2z6i FMN2-nitropropane dioxygenase / 0.735
3p8i FMNPentaerythritol tetranitrate reductase / 0.733
3p8j FMNPentaerythritol tetranitrate reductase / 0.730
4jic FMNGTN Reductase / 0.730
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.727
2abb FMNPentaerythritol tetranitrate reductase / 0.726
3aty FMNProstaglandin F2a synthase / 0.725
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.724
3atz FMNProstaglandin F2a synthase / 0.724
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.722
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.722
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.721
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.721
3f03 FMNPentaerythritol tetranitrate reductase / 0.719
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.719
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.718
3p67 FMNPentaerythritol tetranitrate reductase / 0.713
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.713
5cpm FNRNADH:flavin oxidoreductase / 0.713
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.705
4df2 FMNNADPH dehydrogenase / 0.702
4qai FMNNADPH dehydrogenase / 0.702
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.700
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.699
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.696
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.691
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.688
3p82 FMNPentaerythritol tetranitrate reductase / 0.688
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.684
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.683
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.683
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.682
1d7y FADFerredoxin reductase / 0.681
3bw4 FMNPutative 2-nitropropane dioxygenase / 0.681
2gr3 FADFerredoxin reductase / 0.680
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.678
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.678
3fst FAD5,10-methylenetetrahydrofolate reductase 1.5.1.20 0.678
3w8w FADPutative FAD-dependent oxygenase EncM / 0.678
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.678
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.676
2rds 1PL1-deoxypentalenic acid 11-beta-hydroxylase 1.14.11.35 0.671
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.670
1nqu RDL6,7-dimethyl-8-ribityllumazine synthase 2.5.1.78 0.669
2ohj FMNType A flavoprotein FprA 1 0.668
4cw5 FMNDfnA / 0.668
3icr COACoenzyme A disulfide reductase / 0.667
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.666
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.666
1eje FMNProtein MTH_152 / 0.665
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.662
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.661
1q1w FADPutidaredoxin reductase 1.18.1.5 0.661
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.661
1vyr FMNPentaerythritol tetranitrate reductase / 0.661
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
4nmc FADBifunctional protein PutA / 0.657
4hut ATPCob(I)yrinic acid a,c-diamide adenosyltransferase 2.5.1.17 0.653
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.652
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.652
2gjl FMNNitronate monooxygenase 1.13.12.16 0.652
3ewy U5PUridine 5'-monophosphate synthase 4.1.1.23 0.651
1buc FADAcyl-CoA dehydrogenase, short-chain specific 1.3.8.1 0.650
1nqv LMZ6,7-dimethyl-8-ribityllumazine synthase 2.5.1.78 0.650
4df8 0L4DNA polymerase I, thermostable 2.7.7.7 0.650