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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j3i NAP NADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j3i NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 1.046
4b7x NAPProbable oxidoreductase / 0.697
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.682
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.677
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.677
1uxj NADMalate dehydrogenase / 0.667
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.665
1iyz NDPProbable quinone oxidoreductase / 0.664
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.663
3jv7 NADSecondary alcohol dehydrogenase / 0.661
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.659
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.658
1qlh NADAlcohol dehydrogenase E chain 1.1.1.1 0.654
1uxk NADMalate dehydrogenase / 0.654
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.651
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.650