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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j0m 4ST Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j0m 4STFocal adhesion kinase 1 2.7.10.2 1.029
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.868
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.855
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.855
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.848
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.846
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.801
3zew STUEphrin type-B receptor 4 2.7.10.1 0.800
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.792
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.784
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.774
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.765
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.761
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.758
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.755
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.751
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.749
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.741
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.732
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.732
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.726
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.724
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.715
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.714
3cqe P91Wee1-like protein kinase 2.7.10.2 0.712
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.704
2buj STUSerine/threonine-protein kinase 16 / 0.682
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.680
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.678
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.677
4e5f 0N7Polymerase acidic protein / 0.660
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.650