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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iwx M1S ATP-dependent molecular chaperone HSP82

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.976
2cgf P2NATP-dependent molecular chaperone HSP82 / 0.911
2iws NP4ATP-dependent molecular chaperone HSP82 / 0.854
3inw JZBHeat shock protein HSP 90-alpha / 0.852
4egk RDCHeat shock protein HSP 90-alpha / 0.831
2wer RDCATP-dependent molecular chaperone HSP82 / 0.823
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.814
2xd6 XD6ATP-dependent molecular chaperone HSP82 / 0.813
1qy8 RDIEndoplasmin / 0.812
2fxs RDAATP-dependent molecular chaperone HSP82 / 0.808
4ce1 7FKATP-dependent molecular chaperone HSP82 / 0.775
2bre KJ2ATP-dependent molecular chaperone HSP82 / 0.774
2gfd RDAEndoplasmin / 0.764
4bqj XKLHeat shock protein HSP 90-alpha / 0.756
4b7p 9UNHeat shock protein HSP 90-alpha / 0.755
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.751
3inx JZCHeat shock protein HSP 90-alpha / 0.750
4ce2 BO5ATP-dependent molecular chaperone HSP82 / 0.744
2fyp RDEEndoplasmin / 0.742
3eko PYUHeat shock protein HSP 90-alpha / 0.736
1yc4 43PHeat shock protein HSP 90-alpha / 0.719
1u0z RDCEndoplasmin / 0.701
2xab VHDHeat shock protein HSP 90-alpha / 0.697
2ye4 2FYHeat shock protein HSP 90-alpha / 0.695
3k99 PFTHeat shock protein HSP 90-alpha / 0.687
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.687
4mpc PV2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.683
2xx4 13IATP-dependent molecular chaperone HSP82 / 0.681
2yk2 YJWHeat shock protein HSP 90-alpha / 0.675
3ekr PY9Heat shock protein HSP 90-alpha / 0.675
2yjw YJWHeat shock protein HSP 90-alpha / 0.674
1bgq RDCATP-dependent molecular chaperone HSP82 / 0.671
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.670
2xx2 13CATP-dependent molecular chaperone HSP82 / 0.667
2yei XQIHeat shock protein HSP 90-alpha / 0.667
2xjj L81Heat shock protein HSP 90-alpha / 0.666
2xjx XJXHeat shock protein HSP 90-alpha / 0.666
2byi 2DDHeat shock protein HSP 90-alpha / 0.664
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.660
1nmd ATPMajor actin / 0.660
1xxj UNCUricase 1.7.3.3 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
2d09 FLVBiflaviolin synthase CYP158A2 / 0.660
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.660
2oap ANPType II secretion system protein (GspE-2) / 0.660
2q8i RDC[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial 2.7.11.2 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
3cwq ADPParA family chromosome partitioning protein / 0.660
3f8p NADNADH oxidase/thioredoxin reductase / 0.660
3fzf ATPHeat shock cognate 71 kDa protein / 0.660
3u9d ATPActin, alpha skeletal muscle / 0.660
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.660
4e5l DBHPolymerase acidic protein / 0.660
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.660
4afj SJJGlycogen synthase kinase-3 beta 2.7.11.26 0.659
2brc CT5ATP-dependent molecular chaperone HSP82 / 0.654
2yec XQ0Heat shock protein HSP 90-alpha / 0.654
1m78 CLZDihydrofolate reductase 1.5.1.3 0.653