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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iw8 4SP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2iw8 4SPCyclin-dependent kinase 2 2.7.11.22 0.960
4eor 4SPCyclin-dependent kinase 2 2.7.11.22 0.897
2iw9 4SPCyclin-dependent kinase 2 2.7.11.22 0.852
1h1s 4SPCyclin-dependent kinase 2 2.7.11.22 0.849
1oiu N76Cyclin-dependent kinase 2 2.7.11.22 0.837
1oi9 N20Cyclin-dependent kinase 2 2.7.11.22 0.784
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.784
1h1q 2A6Cyclin-dependent kinase 2 2.7.11.22 0.780
3r9d X6BCyclin-dependent kinase 2 2.7.11.22 0.768
1oiy N41Cyclin-dependent kinase 2 2.7.11.22 0.749
3r9h Z67Cyclin-dependent kinase 2 2.7.11.22 0.734
1h1r 6CPCyclin-dependent kinase 2 2.7.11.22 0.727
4eok 4SPCyclin-dependent kinase 2 2.7.11.22 0.727
2c6o 4SPCyclin-dependent kinase 2 2.7.11.22 0.725
3rmf 20ZCyclin-dependent kinase 2 2.7.11.22 0.704
1ogu ST8Cyclin-dependent kinase 2 2.7.11.22 0.693
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.693
2c6m DT5Cyclin-dependent kinase 2 2.7.11.22 0.680
3qyw 6PBMitogen-activated protein kinase 1 2.7.11.24 0.673
2c6i DT1Cyclin-dependent kinase 2 2.7.11.22 0.671
1gz8 MBPCyclin-dependent kinase 2 2.7.11.22 0.670
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.668
3qu0 X40Cyclin-dependent kinase 2 2.7.11.22 0.668
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.663
1y8y CT7Cyclin-dependent kinase 2 2.7.11.22 0.657
2c6t DT5Cyclin-dependent kinase 2 2.7.11.22 0.654