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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2itq ITQ Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2itq ITQEpidermal growth factor receptor 2.7.10.1 0.894
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.677
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.664
4e5f 0N7Polymerase acidic protein / 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.659
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.652