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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iqg F2I Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2iqg F2IBeta-secretase 1 3.4.23.46 1.371
3cib 314Beta-secretase 1 3.4.23.46 1.186
3cid 318Beta-secretase 1 3.4.23.46 1.152
3cic 316Beta-secretase 1 3.4.23.46 1.137
3lpk Z76Beta-secretase 1 3.4.23.46 1.130
3lpi Z74Beta-secretase 1 3.4.23.46 1.093
2p83 MR0Beta-secretase 1 3.4.23.46 1.057
2hm1 LIQBeta-secretase 1 3.4.23.46 0.978
3lpj Z75Beta-secretase 1 3.4.23.46 0.976
2vnm CM8Beta-secretase 1 3.4.23.46 0.947
3nsh 957Beta-secretase 1 3.4.23.46 0.925
4i0i 957Beta-secretase 1 3.4.23.46 0.925
2vie VG0Beta-secretase 1 3.4.23.46 0.922
2wf0 ZY0Beta-secretase 1 3.4.23.46 0.922
3k5c 0BIBeta-secretase 1 3.4.23.46 0.922
2xfj VG5Beta-secretase 1 3.4.23.46 0.921
4dpi 0N1Beta-secretase 1 3.4.23.46 0.918
3k5g BJCBeta-secretase 1 3.4.23.46 0.909
3veu 0GOBeta-secretase 1 3.4.23.46 0.908
2vj6 VG5Beta-secretase 1 3.4.23.46 0.906
2xfk AA9Beta-secretase 1 3.4.23.46 0.904
2vnn CM7Beta-secretase 1 3.4.23.46 0.901
2viy VG3Beta-secretase 1 3.4.23.46 0.897
2vij C44Beta-secretase 1 3.4.23.46 0.896
2xfi XFIBeta-secretase 1 3.4.23.46 0.891
4fco 0U4Beta-secretase 1 3.4.23.46 0.889
4dpf 0LGBeta-secretase 1 3.4.23.46 0.888
3ohf 3HFBeta-secretase 1 3.4.23.46 0.887
2p8h MY9Beta-secretase 1 3.4.23.46 0.876
1w51 L01Beta-secretase 1 3.4.23.46 0.870
4lxk 1YTBeta-secretase 1 3.4.23.46 0.866
2wf4 ZY4Beta-secretase 1 3.4.23.46 0.862
4lxa 1YSBeta-secretase 1 3.4.23.46 0.860
2hiz LIJBeta-secretase 1 3.4.23.46 0.856
3i25 MV7Beta-secretase 1 3.4.23.46 0.853
4lxm 1YUBeta-secretase 1 3.4.23.46 0.849
2vj9 VG7Beta-secretase 1 3.4.23.46 0.844
3ohh 3HHBeta-secretase 1 3.4.23.46 0.844
4k9h 1QUBeta-secretase 1 3.4.23.46 0.839
2b8l 5HABeta-secretase 1 3.4.23.46 0.829
4d89 BXDBeta-secretase 1 3.4.23.46 0.829
3ixj 586Beta-secretase 1 3.4.23.46 0.828
4k8s 1QTBeta-secretase 1 3.4.23.46 0.824
2wf3 ZY3Beta-secretase 1 3.4.23.46 0.823
4i0j 842Beta-secretase 1 3.4.23.46 0.819
4ke1 1R6Beta-secretase 1 3.4.23.46 0.819
3dv5 BAVBeta-secretase 1 3.4.23.46 0.818
3pi5 3P5Beta-secretase 1 3.4.23.46 0.810
3vf3 0GSBeta-secretase 1 3.4.23.46 0.807
2vkm BSDBeta-secretase 1 3.4.23.46 0.803
3k5f AYHBeta-secretase 1 3.4.23.46 0.800
3vg1 0GTBeta-secretase 1 3.4.23.46 0.798
3qbh QBHBeta-secretase 1 3.4.23.46 0.785
2viz VG4Beta-secretase 1 3.4.23.46 0.774
3skg PB8Beta-secretase 1 3.4.23.46 0.774
2qzl IXSBeta-secretase 1 3.4.23.46 0.765
3ixk 929Beta-secretase 1 3.4.23.46 0.761
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.754
2g94 ZPQBeta-secretase 1 3.4.23.46 0.749
3dm6 757Beta-secretase 1 3.4.23.46 0.748
3dv1 AR9Beta-secretase 1 3.4.23.46 0.745
2f3e AXQBeta-secretase 1 3.4.23.46 0.738
2fdp FRPBeta-secretase 1 3.4.23.46 0.738
2p4j 23IBeta-secretase 1 3.4.23.46 0.737
3duy AFJBeta-secretase 1 3.4.23.46 0.730
2b8v 3BNBeta-secretase 1 3.4.23.46 0.729
2f3f AXFBeta-secretase 1 3.4.23.46 0.721
1e80 0GQEndothiapepsin 3.4.23.22 0.717
3r2f PB0Beta-secretase 1 3.4.23.46 0.715
2ntr L00Beta-secretase 1 3.4.23.46 0.709
4gid 0GHBeta-secretase 1 3.4.23.46 0.709
3n4l 842Beta-secretase 1 3.4.23.46 0.707
1gvw 0EMEndothiapepsin 3.4.23.22 0.704
3k5d XLIBeta-secretase 1 3.4.23.46 0.701
2vj7 VG6Beta-secretase 1 3.4.23.46 0.697
2jji 0QSEndothiapepsin 3.4.23.22 0.692
2jjj 0QSEndothiapepsin 3.4.23.22 0.689
2oah QINBeta-secretase 1 3.4.23.46 0.689
1xe6 5FPPlasmepsin-2 3.4.23.39 0.687
1gvt 2ZSEndothiapepsin 3.4.23.22 0.679
1zap A70Candidapepsin-2 3.4.23.24 0.679
3tpr 5HABeta-secretase 1 3.4.23.46 0.678
1psa 0ZLPepsin A 3.4.23.1 0.676
1bil 0IURenin 3.4.23.15 0.670
4ewo 996Beta-secretase 1 3.4.23.46 0.669
2wez ZYEBeta-secretase 1 3.4.23.46 0.659
3own 3OXRenin 3.4.23.15 0.657
1eag A70Candidapepsin-2 3.4.23.24 0.655
3prs RITEndothiapepsin 3.4.23.22 0.655
1w6h TITPlasmepsin-2 3.4.23.39 0.650