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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2in6 839 Wee1-like protein kinase 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2in6 839Wee1-like protein kinase 2.7.10.2 1.089
3biz 61EWee1-like protein kinase 2.7.10.2 0.979
1x8b 824Wee1-like protein kinase 2.7.10.2 0.944
2z2w 770Wee1-like protein kinase 2.7.10.2 0.943
3bi6 396Wee1-like protein kinase 2.7.10.2 0.935
3cqe P91Wee1-like protein kinase 2.7.10.2 0.867
3cr0 809Wee1-like protein kinase 2.7.10.2 0.778
4c58 824Cyclin-G-associated kinase 2.7.11.1 0.748
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.744
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.737
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.737
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.714
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.714
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.712
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.710
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.693
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.691
4fv9 E71Mitogen-activated protein kinase 1 2.7.11.24 0.679
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.653
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.653
2vd5 BI8Myotonin-protein kinase 2.7.11.1 0.652
4bgg 844Activin receptor type-1 2.7.11.30 0.650