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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ikh LIT Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ikh LITAldose reductase 1.1.1.21 0.821
2ikj 393Aldose reductase 1.1.1.21 0.709
3m4h 388Aldose reductase 1.1.1.21 0.707
3ght LDTAldose reductase 1.1.1.21 0.706
2pdc 393Aldose reductase 1.1.1.21 0.694
3m64 393Aldose reductase 1.1.1.21 0.692
2inz OHPAldose reductase 1.1.1.21 0.685
2pdm ZSTAldose reductase 1.1.1.21 0.685
2duz ZSTAldose reductase 1.1.1.21 0.684
2pdi ZSTAldose reductase 1.1.1.21 0.684
3m0i ZSTAldose reductase 1.1.1.21 0.680
3ghu LDTAldose reductase 1.1.1.21 0.679
2pdp 393Aldose reductase 1.1.1.21 0.678
2ipw 2CLAldose reductase 1.1.1.21 0.677
2pdj 393Aldose reductase 1.1.1.21 0.676
2nvc ITAAldose reductase 1.1.1.21 0.675
2pdu 393Aldose reductase 1.1.1.21 0.675
3mc5 393Aldose reductase 1.1.1.21 0.675
4yu1 53NAldose reductase 1.1.1.21 0.674
1us0 LDTAldose reductase 1.1.1.21 0.673
2i16 LDTAldose reductase 1.1.1.21 0.673
2qxw LDTAldose reductase 1.1.1.21 0.673
2fz9 ZSTAldose reductase 1.1.1.21 0.672
2pdq 47DAldose reductase 1.1.1.21 0.669
2fzd TOLAldose reductase 1.1.1.21 0.668
2dv0 ZSTAldose reductase 1.1.1.21 0.666
2pdb ZSTAldose reductase 1.1.1.21 0.666
1frb ZSTAldose reductase-related protein 2 / 0.665
2hvo ZSTAldose reductase 1.1.1.21 0.665
2pzn 393Aldose reductase 1.1.1.21 0.665
2pdl TOLAldose reductase 1.1.1.21 0.662
3s3g TLTAldose reductase 1.1.1.21 0.651