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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ihu TP9 N(2)-(2-carboxyethyl)arginine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 1.224
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 1.040
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.987
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.976
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.973
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.967
2pan TDPGlyoxylate carboligase 4.1.1.47 0.839
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.836
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.820
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.811
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.786
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.784
4cok TPPPyruvate decarboxylase / 0.783
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.782
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.779
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.779
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.777
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.770
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.770
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.769
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.769
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.768
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.764
2ag0 TPPBenzaldehyde lyase / 0.763
2ezt TDMPyruvate oxidase 1.2.3.3 0.763
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.762
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.762
2c42 TPPPyruvate synthase / 0.759
1y9d TPPPyruvate oxidase 1.2.3.3 0.757
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.752
2c3u 2TPPyruvate synthase / 0.751
3d7k D7KBenzaldehyde lyase / 0.749
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.749
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.744
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.739
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.739
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.733
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.732
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.731
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.728
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.728
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.727
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.727
3iae D7KBenzaldehyde lyase / 0.727
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.726
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.724
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.722
1pox TPPPyruvate oxidase 1.2.3.3 0.720
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 0.720
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.717
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.716
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.716
1kek HTLPyruvate synthase / 0.715
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.713
2uz1 TPPBenzaldehyde lyase / 0.713
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.713
4qpz TPPBenzaldehyde lyase / 0.713
5c4i TPPOxalate oxidoreductase subunit alpha / 0.712
5c4i TPPOxalate oxidoreductase subunit beta / 0.712
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.711
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.711
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.710
2uza HTLPyruvate synthase / 0.710
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.709
5ahk TPPAcetolactate synthase II, large subunit / 0.709
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.707
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.707
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.706
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.705
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.704
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.703
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.702
2o1x TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.702
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.700
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.700
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.699
2ez9 TDKPyruvate oxidase 1.2.3.3 0.696
2c3y HTLPyruvate synthase / 0.695
1tkc M6TTransketolase 1 2.2.1.1 0.693
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.693
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.691
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.691
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.691
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.687
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.686
1gpu THDTransketolase 1 2.2.1.1 0.683
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.683
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.683
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.683
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.683
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.683
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.683
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.682
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.682
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.682
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.682
2r8p T6FTransketolase 1 / 0.681
3upt TPPTransketolase / 0.681
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.679
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.678
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.678
1pow TPPPyruvate oxidase 1.2.3.3 0.678
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.678
2c3o TPPPyruvate synthase / 0.677
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.675
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.674
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.674
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.674
3ahj TPPProbable phosphoketolase / 0.673
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.671
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.670
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.670
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.669
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.667
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.667
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.667
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.664
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.663
2pda TPPPyruvate synthase / 0.662
1ay0 TPPTransketolase 1 2.2.1.1 0.658
2bc9 GNPGuanylate-binding protein 1 / 0.658
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 0.658
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.656
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.655
5exd TPPOxalate oxidoreductase subunit alpha / 0.655
5exd TPPOxalate oxidoreductase subunit beta / 0.655
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.654