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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2id2 NAP NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 1.361
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 1.075
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.903
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.894
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.880
3b4w NADAldehyde dehydrogenase family protein / 0.863
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.861
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.861
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.857
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.856
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.855
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.855
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.849
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.844
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.842
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.840
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.836
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.835
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.831
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.828
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.826
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.825
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.820
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.816
4i8q NADPutative betaine aldehyde dehyrogenase / 0.814
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.811
4i8p NADAminoaldehyde dehydrogenase 1 / 0.810
4pz2 NADAldehyde dehydrogenase 2-6 / 0.810
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.807
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.801
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.800
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.799
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.792
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.791
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.789
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.785
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.783
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.781
4nmk NAPAldehyde dehydrogenase / 0.776
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.773
2jg7 NADAntiquitin / 0.771
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.770
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.761
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.747
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.746
4c3s NADAldehyde Dehydrogenase / 0.741
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.740
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.728
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.719
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.718
4i3v NADAldehyde dehydrogenase (NAD+) / 0.717
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.709
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.706
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.696
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.691
4nmj NAPAldehyde dehydrogenase / 0.681
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.678
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.675
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.667
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.665
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.665
3haz NADBifunctional protein PutA / 0.660
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.660
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.659
4h73 NDPAldehyde dehydrogenase / 0.659
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654