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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hzn KIN Tyrosine-protein kinase ABL1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 1.216
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.845
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.824
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.823
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.812
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.779
3b8q 900Vascular endothelial growth factor receptor 2 2.7.10.1 0.770
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.755
3gcs BAXMitogen-activated protein kinase 14 / 0.748
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.745
3ugc 046Tyrosine-protein kinase JAK2 / 0.736
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.725
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.724
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.723
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.710
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.707
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.700
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.699
3b8r 887Vascular endothelial growth factor receptor 2 2.7.10.1 0.697
3gi3 B10Mitogen-activated protein kinase 14 / 0.681
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.675
3qlf PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.671
3tub FPUTyrosine-protein kinase SYK 2.7.10.2 0.665
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.663
2yis YISMitogen-activated protein kinase 14 / 0.662
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.661
3nnw EDDMitogen-activated protein kinase 14 / 0.660
3hv3 R49Mitogen-activated protein kinase 14 / 0.659
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.658
3hv7 1AUMitogen-activated protein kinase 14 / 0.655
4olm 198Androgen receptor / 0.655
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.652