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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hy0 306 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.978
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.861
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.781
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.776
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.770
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.762
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.733
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.723
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.722
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.719
4ftk H9KSerine/threonine-protein kinase Chk1 2.7.11.1 0.711
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.710
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.701
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.697
3g0e B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.691
4im0 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.687
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.683
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.673
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.672
2xne ASHAurora kinase A 2.7.11.1 0.672
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.670
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.669
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.664
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.663
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4jbq VX6Aurora kinase A 2.7.11.1 0.659
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.658
3g0f B49Mast/stem cell growth factor receptor Kit 2.7.10.1 0.656
2wmt ZYTSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3vid 4TTVascular endothelial growth factor receptor 2 2.7.10.1 0.650
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.650