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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hxl 422 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.946
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.869
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.728
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.728
2c3l IDZSerine/threonine-protein kinase Chk1 2.7.11.1 0.726
4f64 0S8Fibroblast growth factor receptor 1 / 0.719
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.715
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.710
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.710
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
3w2c N15Aurora kinase A 2.7.11.1 0.704
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.703
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.701
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.694
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.693
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.693
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.691
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.689
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.689
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.688
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.687
3r8l Z30Cyclin-dependent kinase 2 2.7.11.22 0.684
3w16 P9JAurora kinase A 2.7.11.1 0.683
1oec AA2Fibroblast growth factor receptor 2 / 0.682
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.681
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.680
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
2w1g L0GAurora kinase A 2.7.11.1 0.678
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.677
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
4f63 0S7Fibroblast growth factor receptor 1 / 0.676
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.673
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.672
2zmd 537Dual specificity protein kinase TTK 2.7.12.1 0.669
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.668
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.668
4ftk H9KSerine/threonine-protein kinase Chk1 2.7.11.1 0.668
4bkz 1WSMaternal embryonic leucine zipper kinase 2.7.11.1 0.667
3ggf GVDSerine/threonine-protein kinase 26 / 0.666
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.665
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.665
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.664
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.662
4ftq 4HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.661
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.660
2w1f L0FAurora kinase A 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.660
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.659
4im0 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.658
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.656
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.655
4oti MI1Serine/threonine-protein kinase N1 / 0.655
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.654
4jlc SU6Serine/threonine-protein kinase TBK1 2.7.11.1 0.654
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2xng A0HAurora kinase A 2.7.11.1 0.653
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.653
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.653
4b0g VEKAurora kinase A 2.7.11.1 0.653
4c58 824Cyclin-G-associated kinase 2.7.11.1 0.653
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4jbq VX6Aurora kinase A 2.7.11.1 0.652
2cdz 23DSerine/threonine-protein kinase PAK 4 2.7.11.1 0.651