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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hv5 ZST Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hv5 ZSTAldose reductase 1.1.1.21 1.206
2fz9 ZSTAldose reductase 1.1.1.21 1.144
2fz8 ZSTAldose reductase 1.1.1.21 1.122
2dux ZSTAldose reductase 1.1.1.21 1.121
2dv0 ZSTAldose reductase 1.1.1.21 1.095
2hvn ZSTAldose reductase 1.1.1.21 1.090
2duz ZSTAldose reductase 1.1.1.21 1.079
2pdm ZSTAldose reductase 1.1.1.21 1.056
2hvo ZSTAldose reductase 1.1.1.21 1.051
2pdi ZSTAldose reductase 1.1.1.21 1.042
3len ZSTAldose reductase 1.1.1.21 1.030
2pdb ZSTAldose reductase 1.1.1.21 1.016
3m0i ZSTAldose reductase 1.1.1.21 1.006
2pdx ZSTAldose reductase 1.1.1.21 0.998
2pd5 ZSTAldose reductase 1.1.1.21 0.930
2pdq 47DAldose reductase 1.1.1.21 0.917
3mb9 ZSTAldose reductase 1.1.1.21 0.914
4gca 2X9Aldose reductase 1.1.1.21 0.888
2pdf ZSTAldose reductase 1.1.1.21 0.840
2pdh 47DAldose reductase 1.1.1.21 0.804
2ikj 393Aldose reductase 1.1.1.21 0.800
2pdn 47DAldose reductase 1.1.1.21 0.800
3g5e Q74Aldose reductase 1.1.1.21 0.785
2pdp 393Aldose reductase 1.1.1.21 0.776
1frb ZSTAldose reductase-related protein 2 / 0.772
1z3n 3NAAldose reductase 1.1.1.21 0.768
3mc5 393Aldose reductase 1.1.1.21 0.756
2pdj 393Aldose reductase 1.1.1.21 0.751
1t40 ID5Aldose reductase 1.1.1.21 0.735
3m64 393Aldose reductase 1.1.1.21 0.728
2pdu 393Aldose reductase 1.1.1.21 0.713
2nvc ITAAldose reductase 1.1.1.21 0.710
2pzn 393Aldose reductase 1.1.1.21 0.709
3t42 3T4Aldose reductase 1.1.1.21 0.707
3ld5 LDTAldose reductase 1.1.1.21 0.698
3lbo LDTAldose reductase 1.1.1.21 0.687
3ghu LDTAldose reductase 1.1.1.21 0.684
3ght LDTAldose reductase 1.1.1.21 0.683
3lz5 LDTAldose reductase 1.1.1.21 0.683
2pdc 393Aldose reductase 1.1.1.21 0.678
2pdg 47DAldose reductase 1.1.1.21 0.675
3s3g TLTAldose reductase 1.1.1.21 0.664
3lql LDTAldose reductase 1.1.1.21 0.663
1t41 ID5Aldose reductase 1.1.1.21 0.656
3ghs LDTAldose reductase 1.1.1.21 0.654