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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hsa FMN 12-oxophytodienoate reductase 3 1.3.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 1.368
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.233
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.217
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 1.190
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 1.147
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 1.087
4qnw FMNChanoclavine-I aldehyde reductase easA / 1.023
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 1.004
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.988
3l67 FMNXenobiotic reductase / 0.978
3p62 FMNPentaerythritol tetranitrate reductase / 0.974
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.972
3l5l FMNXenobiotic reductase / 0.963
4uth FMNXenobiotic reductase / 0.943
4utm FNRXenobiotic reductase / 0.943
4utl FNRXenobiotic reductase / 0.934
3p74 FMNPentaerythritol tetranitrate reductase / 0.933
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.921
3n19 FNRXenobiotic reductase / 0.921
3hf3 FMNChromate reductase / 0.919
3n14 FMNXenobiotic reductase / 0.911
1z48 FMNNADPH dehydrogenase / 0.908
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.902
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.899
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.896
4utk FNRXenobiotic reductase / 0.896
1z41 FMNNADPH dehydrogenase / 0.891
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.891
2h8x FMNXenA / 0.890
4df2 FMNNADPH dehydrogenase / 0.879
4tmb FMNOld yellow enzyme / 0.878
3p8i FMNPentaerythritol tetranitrate reductase / 0.869
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.867
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.863
4tmc FMNOld yellow enzyme / 0.861
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.857
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.856
2zfa FMNLactate oxidase / 0.856
1vyr FMNPentaerythritol tetranitrate reductase / 0.855
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.851
1z44 FMNNADPH dehydrogenase / 0.851
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.849
1h50 FMNPentaerythritol tetranitrate reductase / 0.849
3aty FMNProstaglandin F2a synthase / 0.849
4e2d FMNDehydrogenase / 0.847
2j6x FMNLactate oxidase / 0.843
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.843
3p84 FMNPentaerythritol tetranitrate reductase / 0.837
3p8j FMNPentaerythritol tetranitrate reductase / 0.837
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.836
3f03 FMNPentaerythritol tetranitrate reductase / 0.836
2abb FMNPentaerythritol tetranitrate reductase / 0.835
1vhn FMNtRNA-dihydrouridine synthase / 0.833
4jic FMNGTN Reductase / 0.833
1h63 FMNPentaerythritol tetranitrate reductase / 0.832
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.829
1gwj FMNMorphinone reductase / 0.828
4qai FMNNADPH dehydrogenase / 0.826
5ebu FMNLactate oxidase / 0.825
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.822
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.819
1h51 FMNPentaerythritol tetranitrate reductase / 0.818
3atz FMNProstaglandin F2a synthase / 0.817
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.814
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.814
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.812
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.810
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.810
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.804
2du2 FMNLactate oxidase / 0.803
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.803
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.800
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.800
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.798
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.796
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.793
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.793
4e2b FMNDehydrogenase / 0.792
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.792
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.790
3p67 FMNPentaerythritol tetranitrate reductase / 0.787
2z6i FMN2-nitropropane dioxygenase / 0.786
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.785
3p82 FMNPentaerythritol tetranitrate reductase / 0.779
3tjl FMNNADPH dehydrogenase / 0.776
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.776
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.775
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.774
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.769
3gka FMNN-ethylmaleimide reductase / 0.765
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.763
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.763
5cpm FNRNADH:flavin oxidoreductase / 0.760
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.758
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.756
4yl2 FMNLactate oxidase / 0.756
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.754
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.753
2e77 FMNLactate oxidase / 0.747
4rje FNRLactate oxidase / 0.746
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.739
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.738
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.733
2gjl FMNNitronate monooxygenase 1.13.12.16 0.727
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.708
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.697
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.694
4m5p FMNNADPH dehydrogenase / 0.694
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.692
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.692
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.692
3mdd FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.687
3esz FMNFlavodoxin / 0.685
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.684
1p4m FMNRiboflavin kinase 2.7.1.26 0.682
2eba FADPutative glutaryl-CoA dehydrogenase / 0.680
2vyx FMNDodecin / 0.679
2gjn FMNNitronate monooxygenase 1.13.12.16 0.678
3fst FAD5,10-methylenetetrahydrofolate reductase 1.5.1.20 0.678
4zoh FADPutative oxidoreductase FAD-binding subunit / 0.677
1yrx FMNAppA protein / 0.676
3w77 FMNFMN-dependent NADH-azoreductase / 0.672
4kuk RBFPutative blue-light photoreceptor / 0.672
4e5o UMPThymidylate synthase 2.1.1.45 0.671
2hfo FMNActivator of photopigment and puc expression / 0.670
4nmd FDABifunctional protein PutA / 0.666
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.665
1x0p FADTll0078 protein / 0.665
3bm1 FMNPutative NAD(P)H nitroreductase YdjA / 0.664
3w8w FADPutative FAD-dependent oxygenase EncM / 0.664
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.663
2ix5 FADAcyl-coenzyme A oxidase 4, peroxisomal 1.3.3.6 0.662
4yco FMNtRNA-dihydrouridine(16) synthase / 0.662
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.661
1buc FADAcyl-CoA dehydrogenase, short-chain specific 1.3.8.1 0.660
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.660
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.659
1efv FADElectron transfer flavoprotein subunit alpha, mitochondrial / 0.658
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.658
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.658
4opi FDAConserved Archaeal protein / 0.658
2pdt FADVivid PAS protein VVD / 0.657
4opl FDAConserved Archaeal protein / 0.657
4opt FDAConserved Archaeal protein / 0.657
4yus FMNFamily 3 adenylate cyclase / 0.657
1ege FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.656
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.656
4opu FDAConserved Archaeal protein / 0.656
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.656
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.656
4nt0 3DUOrotidine 5'-phosphate decarboxylase 4.1.1.23 0.655
4opg FDAConserved Archaeal protein / 0.655
1vfr FMNMajor NAD(P)H-flavin oxidoreductase 1.6.99 0.654
2hfn FMNActivator of photopigment and puc expression / 0.654
3fsu FAD5,10-methylenetetrahydrofolate reductase 1.5.1.20 0.654
4r38 RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.654
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.654
1nlv ATPMajor actin / 0.653
1v93 FADMethylenetetrahydrofolate reductase / 0.652
4bby FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.652
4yau 2AMNADPH--cytochrome P450 reductase / 0.652
4eep FMNPhototropin-2 2.7.11.1 0.651
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4yaf 2AMNADPH--cytochrome P450 reductase / 0.651
2a1u FADElectron transfer flavoprotein subunit alpha, mitochondrial / 0.650