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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hog 710 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 1.033
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.869
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.736
3w2c N15Aurora kinase A 2.7.11.1 0.734
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.731
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.716
2c3l IDZSerine/threonine-protein kinase Chk1 2.7.11.1 0.711
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.709
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.706
4f64 0S8Fibroblast growth factor receptor 1 / 0.706
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.704
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.704
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.703
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.702
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.699
4nka 2K7Fibroblast growth factor receptor 1 / 0.696
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.691
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.689
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.687
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.687
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.686
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.683
3w1f 1O5Dual specificity protein kinase TTK 2.7.12.1 0.680
3ggf GVDSerine/threonine-protein kinase 26 / 0.679
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.679
4f63 0S7Fibroblast growth factor receptor 1 / 0.675
4nks 2M2Fibroblast growth factor receptor 1 / 0.675
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.673
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.668
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.666
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.664
3w10 RO9Aurora kinase A 2.7.11.1 0.664
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
3w16 P9JAurora kinase A 2.7.11.1 0.663
5dr6 SKEAurora kinase A 2.7.11.1 0.663
4ftq 4HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1g5s I17Cyclin-dependent kinase 2 2.7.11.22 0.660
1oec AA2Fibroblast growth factor receptor 2 / 0.660
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.660
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.659
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.658
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
3uo5 0BXAurora kinase A 2.7.11.1 0.657
3e5a VX6Aurora kinase A 2.7.11.1 0.656
4qmz B49Serine/threonine-protein kinase 24 2.7.11.1 0.656
2bkz SBCCyclin-dependent kinase 2 2.7.11.22 0.655
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.655
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.655
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.654
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.653
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.653
4bkz 1WSMaternal embryonic leucine zipper kinase 2.7.11.1 0.652
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.651
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.650
2x81 ZZLAurora kinase A 2.7.11.1 0.650
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.650