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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hk5 1BM Tyrosine-protein kinase HCK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hk5 1BMTyrosine-protein kinase HCK 2.7.10.2 1.168
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.724
2zyb KSLTyrosine-protein kinase Lck 2.7.10.2 0.716
4gk2 L66Ephrin type-A receptor 3 2.7.10.1 0.703
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.692
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.678
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4xli 1N1Abelson tyrosine-protein kinase 2 2.7.10.2 0.669
4kip 1R9Mitogen-activated protein kinase 14 / 0.667
3qqg X06Cyclin-dependent kinase 2 2.7.11.22 0.663
2pl0 STITyrosine-protein kinase Lck 2.7.10.2 0.662
2bdj HETProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.657
4dgo 0JWCasein kinase II subunit alpha 2.7.11.1 0.655