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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ha8 SAH Probable methyltransferase TARBP1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ha8 SAHProbable methyltransferase TARBP1 / 1.007
4kgn SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.792
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.789
4pzk SAHPutative tRNA (cytidine(34)-2'-O)-methyltransferase / 0.784
4cng SAHSpoU rRNA methylase / 0.775
4x3l MTARNA 2'-O ribose methyltransferase / 0.775
3n4k SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.751
2egw SAHRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.731
4xbo SAHtRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ 2.1.1.200 0.730
4cnf MTASpoU rRNA methylase / 0.728
4fak SAMRibosomal RNA large subunit methyltransferase H / 0.713
3gyq SAM23S rRNA (adenosine(1067)-2'-O)-methyltransferase / 0.709
3nk7 SAM23S rRNA (adenosine(1067)-2'-O)-methyltransferase / 0.705
3bbd SAHRibosomal RNA small subunit methyltransferase Nep1 2.1.1 0.702
3tw6 ADPPyruvate carboxylase / 0.701
4jal SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.698
2yy8 MTAtRNA (cytidine(56)-2'-O)-methyltransferase / 0.696
2yy8 SAMtRNA (cytidine(56)-2'-O)-methyltransferase / 0.695
2e8h SAHDiphthine synthase / 0.693
2p6d SAHDiphthine synthase / 0.690
2cx8 SAHRibosomal RNA small subunit methyltransferase E / 0.689
2qmm SAMtRNA (pseudouridine(54)-N(1))-methyltransferase / 0.689
1wng SAHDiphthine synthase / 0.688
2ek2 SAHDiphthine synthase / 0.688
2eeq SAHDiphthine synthase / 0.687
2dxv SAHDiphthine synthase / 0.686
2egb SAHDiphthine synthase / 0.686
2egl SAHDiphthine synthase / 0.686
2ehl SAHDiphthine synthase / 0.686
2ek4 SAHDiphthine synthase / 0.685
4jwh SAHtRNA (guanine(9)-N1)-methyltransferase / 0.685
2el3 SAHDiphthine synthase / 0.683
2emr SAHDiphthine synthase / 0.682
2e8r SAHDiphthine synthase / 0.681
2el0 SAHDiphthine synthase / 0.680
2eld SAHDiphthine synthase / 0.680
2huq SAHDiphthine synthase / 0.678
2pb5 SAHDiphthine synthase / 0.678
2hux SAHDiphthine synthase / 0.677
2p5c SAHDiphthine synthase / 0.677
1vce SAHDiphthine synthase / 0.674
2dsg SAHDiphthine synthase / 0.674
2dv7 SAHDiphthine synthase / 0.674
2e15 SAHDiphthine synthase / 0.674
2e8s SAHDiphthine synthase / 0.673
2ed5 SAHDiphthine synthase / 0.673
2egs SAHDiphthine synthase / 0.673
2en5 SAHDiphthine synthase / 0.673
2huv SAHDiphthine synthase / 0.672
2p5f SAHDiphthine synthase / 0.672
2dsh SAHDiphthine synthase / 0.671
2dv3 SAHDiphthine synthase / 0.671
2e16 SAHDiphthine synthase / 0.671
2pca SAHDiphthine synthase / 0.671
2pch SAHDiphthine synthase / 0.671
3o7b SAHRibosomal RNA small subunit methyltransferase Nep1 / 0.671
2p2x SAHDiphthine synthase / 0.670
2ejk SAHDiphthine synthase / 0.669
2pcg SAHDiphthine synthase / 0.669
2zvb SAHPrecorrin-3 C17-methyltransferase / 0.669
2e7r SAHDiphthine synthase / 0.668
3ab8 ATPUncharacterized protein / 0.668
4jwj SAHtRNA (guanine(9)-N1)-methyltransferase / 0.668
2eh5 SAHDiphthine synthase / 0.667
2eka SAHDiphthine synthase / 0.667
3rk1 ATPN-type ATP pyrophosphatase superfamily / 0.666
5ahw CMPUniversal stress protein family protein, putative / 0.666
2qbu SAHPrecorrin-2 methyltransferase / 0.665
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.664
2zvc SAHPrecorrin-3 C17-methyltransferase / 0.664
4fu0 ADPD-alanine--D-alanine ligase / 0.664
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.663
1kp2 ATPArgininosuccinate synthase 6.3.4.5 0.661
5c1p ADPD-alanine--D-alanine ligase / 0.661
2dsi SAHDiphthine synthase / 0.660
2z08 ATPUniversal stress protein family / 0.660
4x3m ADNRNA 2'-O ribose methyltransferase / 0.660
1uam SAHtRNA (guanine-N(1)-)-methyltransferase 2.1.1.228 0.659
2owv SAHDiphthine synthase / 0.658
4h3y SAHtRNA (guanine-N(1)-)-methyltransferase / 0.658
2dv5 SAHDiphthine synthase / 0.657
2eh4 SAHDiphthine synthase / 0.657
3hpq AP5Adenylate kinase / 0.657
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.657
5c1o ANPD-alanine--D-alanine ligase / 0.657
2ejz SAHDiphthine synthase / 0.656
3hpr AP5Adenylate kinase / 0.656
5c77 SAHProtein arginine N-methyltransferase SFM1 / 0.656
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.654
2z0y SAMRibosomal RNA small subunit methyltransferase E / 0.653
2aj4 ANPGalactokinase 2.7.1.6 0.652
2e07 SAHDiphthine synthase / 0.652
2z6r SAHDiphthine synthase / 0.650
3mhy ATPNitrogen regulatory protein P-II 1 / 0.650