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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2h2q NAP Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 1.253
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.975
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.968
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.903
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.884
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.882
3tqa NDPDihydrofolate reductase / 0.870
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.861
1drh NAPDihydrofolate reductase 1.5.1.3 0.861
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.852
5ecc NAPDehydrofolate reductase type I / 0.828
3qls NDPDihydrofolate reductase 1.5.1.3 0.822
2cig 1DGDihydrofolate reductase 1.5.1.3 0.815
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.782
3dg8 NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.772
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.749
1m78 NDPDihydrofolate reductase 1.5.1.3 0.739
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.736
4m6j NDPDihydrofolate reductase 1.5.1.3 0.736
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.734
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.733
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.724
3qlr NDPDihydrofolate reductase 1.5.1.3 0.716
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.707
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.677
1jq5 NADGlycerol dehydrogenase 1.1.1.6 0.662
8dfr NDPDihydrofolate reductase 1.5.1.3 0.660