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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gzw CMP cAMP-activated global transcriptional regulator CRP

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gzw CMPcAMP-activated global transcriptional regulator CRP / 0.928
4ft8 CMPcAMP-activated global transcriptional regulator CRP / 0.838
1g6n CMPcAMP-activated global transcriptional regulator CRP / 0.833
4hzf CMPcAMP-activated global transcriptional regulator CRP / 0.813
4i0a CMPcAMP-activated global transcriptional regulator CRP / 0.810
1zrd CMPcAMP-activated global transcriptional regulator CRP / 0.800
3ryp CMPcAMP-activated global transcriptional regulator CRP / 0.800
3kcc CMPcAMP-activated global transcriptional regulator CRP / 0.799
4i0b CMPcAMP-activated global transcriptional regulator CRP / 0.795
4r8h SP1cAMP-activated global transcriptional regulator CRP / 0.785
4i09 CMPcAMP-activated global transcriptional regulator CRP / 0.782
2cgp CMPcAMP-activated global transcriptional regulator CRP / 0.779
3ryr CMPcAMP-activated global transcriptional regulator CRP / 0.777
4i02 CMPcAMP-activated global transcriptional regulator CRP / 0.772
3n4m CMPcAMP-activated global transcriptional regulator CRP / 0.771
3rpq CMPcAMP-activated global transcriptional regulator CRP / 0.761
2oz6 CMPCyclic AMP receptor-like protein / 0.759
3rdi CMPcAMP-activated global transcriptional regulator CRP / 0.758
1cgp CMPcAMP-activated global transcriptional regulator CRP / 0.752
1i6x CMPcAMP-activated global transcriptional regulator CRP / 0.751
1i5z CMPcAMP-activated global transcriptional regulator CRP / 0.747
1hw5 CMPcAMP-activated global transcriptional regulator CRP / 0.744
1vp6 CMPCyclic nucleotide-gated potassium channel mll3241 / 0.732
3rou CMPcAMP-activated global transcriptional regulator CRP / 0.725
4i01 CMPcAMP-activated global transcriptional regulator CRP / 0.723
1ruo CMPcAMP-activated global transcriptional regulator CRP / 0.715
1q5o CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.708
3cl1 PCGCyclic nucleotide-gated potassium channel mll3241 / 0.693
3u11 CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 / 0.687
3bpz CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.679
1zrc CMPcAMP-activated global transcriptional regulator CRP / 0.678
2ptm CMPHyperpolarization-activated (Ih) channel / 0.678
1ne4 RP1cAMP-dependent protein kinase type I-alpha regulatory subunit / 0.677
3qop CMPcAMP-activated global transcriptional regulator CRP / 0.676
4hbn CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 / 0.675
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.671
1cx4 CMPcAMP-dependent protein kinase type II-beta regulatory subunit / 0.668
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.662
4ku7 PCGcGMP-dependent protein kinase 1 2.7.11.12 0.662
1q3e PCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.661
3u10 CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / 0.661
4qx5 CMPcGMP-dependent protein kinase 1 2.7.11.12 0.659
4jv4 1ORcAMP-dependent protein kinase type I-alpha regulatory subunit / 0.658
4s1b 2BALmo1466 protein / 0.654
3i59 N6SCRP-like cAMP-activated global transcriptional regulator / 0.651
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650