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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gq2 NAP Flavin-dependent thymidylate synthase 2.1.1.148

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gq2 NAPFlavin-dependent thymidylate synthase 2.1.1.148 1.130
4gtl FADFlavin-dependent thymidylate synthase 2.1.1.148 0.742
4p5a FADFlavin-dependent thymidylate synthase / 0.741
2af6 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.717
1kq4 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.700
3gwc FADFlavin-dependent thymidylate synthase 2.1.1.148 0.696
3n0b FADFlavin-dependent thymidylate synthase 2.1.1.148 0.680
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.658
4p5b FADFlavin-dependent thymidylate synthase / 0.653
4ffm ADPUncharacterized protein / 0.650