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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gn4 UD1 UDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gn4 UD1UDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 1.388
2pk3 GDDGDP-6-deoxy-D-mannose reductase / 0.755
1wvg CXYCDP-glucose 4,6-dehydratase 4.2.1.45 0.740
1uda UFGUDP-glucose 4-epimerase 5.1.3.2 0.737
3ruc UD2UDP-N-acetylglucosamine 4-epimerase / 0.731
1a9z UPGUDP-glucose 4-epimerase 5.1.3.2 0.723
4zrn UPGUDP-glucose 4-epimerase, putative / 0.707
3enk UPGUDP-glucose 4-epimerase / 0.703
1sb8 UD2WbpP / 0.699
3ruh UD6UDP-N-acetylglucosamine 4-epimerase / 0.698
3lu1 UD2UDP-N-acetylglucosamine 4-epimerase / 0.697
1a9y UPGUDP-glucose 4-epimerase 5.1.3.2 0.693
3q2k NAIProbable oxidoreductase / 0.689
1kvu UPGUDP-glucose 4-epimerase 5.1.3.2 0.684
4gte FADFlavin-dependent thymidylate synthase 2.1.1.148 0.677
2udp UPPUDP-glucose 4-epimerase 5.1.3.2 0.674
2xgo ZKDUncharacterized protein / 0.674
4lis UPGUDP-glucose 4-epimerase (Eurofung) / 0.672
1sb9 UPGWbpP / 0.671
2qrd ADP5'-AMP-activated protein kinase subunit gamma / 0.671
1kvs UPGUDP-glucose 4-epimerase 5.1.3.2 0.668
4p5a FADFlavin-dependent thymidylate synthase / 0.662
1i3k UPGUDP-glucose 4-epimerase / 0.658
5ios FADFlavin-dependent thymidylate synthase 2.1.1.148 0.652
5a06 NDPGlucose-fructose oxidoreductase / 0.651