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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gmj FAD Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 1.364
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.839
1zx9 FADMercuric reductase 1.16.1.1 0.794
2q7v FADThioredoxin reductase / 0.772
3cn8 FADPolyamine oxidase FMS1 / 0.764
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.761
2zbw FADFerredoxin--NADP reductase / 0.755
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.753
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.753
3cty FADProbable thioredoxin reductase / 0.752
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.746
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.746
4cnk FADL-amino acid oxidase / 0.744
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.740
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.736
3bi5 FADPolyamine oxidase FMS1 / 0.736
4u8k FDAUDP-galactopyranose mutase / 0.736
2yg4 FADPutrescine oxidase / 0.732
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.730
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.727
3cnd FADPolyamine oxidase FMS1 / 0.726
4rsl FADFructosyl peptide oxidase / 0.725
1rsg FADPolyamine oxidase FMS1 / 0.724
4u8p FDAUDP-galactopyranose mutase / 0.723
2e1m FADL-glutamate oxidase / 0.721
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.720
2qa1 FADPgaE / 0.720
3vqr FADPutative oxidoreductase / 0.720
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.717
3k4c FADPyranose 2-oxidase / 0.717
1xpq FADPolyamine oxidase FMS1 / 0.716
5j60 FADThioredoxin reductase / 0.714
1z6l FADPolyamine oxidase FMS1 / 0.713
1yy5 FADPolyamine oxidase FMS1 / 0.712
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.712
4dsg FADUncharacterized protein / 0.712
4k2x FADPolyketide oxygenase/hydroxylase / 0.712
3ad9 FADSubunit beta of sarcosine oxidase / 0.711
4u8i FDAUDP-galactopyranose mutase / 0.711
1tdn FADL-amino-acid oxidase 1.4.3.2 0.710
4opi FDAConserved Archaeal protein / 0.708
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.705
4dsh FDAUncharacterized protein / 0.705
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.705
2b9x FADPutative aminooxidase / 0.704
1tde FADThioredoxin reductase 1.8.1.9 0.703
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.702
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.702
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.702
2ign FADPyranose 2-oxidase / 0.701
2xdo FADTetX family tetracycline inactivation enzyme / 0.701
3kve FADL-amino-acid oxidase / 0.700
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.699
2yg5 FADPutrescine oxidase / 0.699
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.698
4ccq FADThioredoxin reductase / 0.698
4opu FDAConserved Archaeal protein / 0.697
4up3 FADThioredoxin reductase / 0.697
1reo FADL-amino-acid oxidase 1.4.3.2 0.696
3pl8 FADPyranose 2-oxidase / 0.696
4d5g FADCyclohexane-1,2-dione hydrolase 3.7.1.11 0.696
4opg FDAConserved Archaeal protein / 0.696
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
4gdp FADPolyamine oxidase FMS1 / 0.695
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.694
2dw4 FADLysine-specific histone demethylase 1A 1 0.694
4wct FADFructosyl amine:oxygen oxidoreductase / 0.694
4hb9 FADUncharacterized protein / 0.693
3atq FDAConserved Archaeal protein / 0.692
3bi2 FADPolyamine oxidase FMS1 / 0.692
4cbq FADThioredoxin reductase / 0.692
1nhs FADNADH peroxidase 1.11.1.1 0.691
4mo2 FDAUDP-galactopyranose mutase / 0.691
1tdo FADL-amino-acid oxidase 1.4.3.2 0.690
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.690
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.690
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.690
4mo2 FADUDP-galactopyranose mutase / 0.690
1f8s FADL-amino-acid oxidase 1.4.3.2 0.689
1f8w FADNADH peroxidase 1.11.1.1 0.688
2y48 FADLysine-specific histone demethylase 1A 1 0.688
5l3d FADLysine-specific histone demethylase 1A 1 0.688
4opt FDAConserved Archaeal protein / 0.687
3ish FADThioredoxin reductase 1.8.1.9 0.686
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.685
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.684
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.683
2bab FADPutative aminooxidase / 0.683
3p9u FADTetX family tetracycline inactivation enzyme / 0.683
2jb2 FADL-amino acid oxidase / 0.682
4i58 FADCyclohexylamine Oxidase / 0.682
2jb1 FADL-amino acid oxidase / 0.681
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.681
1cc2 FADCholesterol oxidase 1.1.3.6 0.679
2b9w FADPutative aminooxidase / 0.677
2b9y FADPutative aminooxidase / 0.677
4opc FDAConserved Archaeal protein / 0.677
1qo8 FADFumarate reductase flavoprotein subunit / 0.676
2a87 FADThioredoxin reductase 1.8.1.9 0.676
4xbf FADLysine-specific histone demethylase 1A 1 0.676
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.675
3jsk AHZThiamine thiazole synthase / 0.675
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.675
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.674
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.674
1nhp FADNADH peroxidase 1.11.1.1 0.674
2rgh FADAlpha-Glycerophosphate Oxidase / 0.674
3r9u FADThioredoxin reductase / 0.674
5djt FMNNPH1-2 / 0.674
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.674
1tdf FADThioredoxin reductase 1.8.1.9 0.673
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.673
2jae FADL-amino acid oxidase / 0.673
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.673
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.672
2du8 FADD-amino-acid oxidase 1.4.3.3 0.672
2qa2 FADPolyketide oxygenase CabE / 0.672
3gsi FADDimethylglycine oxidase 1.5.3.10 0.672
1geu FADGlutathione reductase 1.8.1.7 0.671
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.671
2yg3 FADPutrescine oxidase / 0.671
4z24 FADPutative GMC-type oxidoreductase R135 1 0.671
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.671
1f8r FADL-amino-acid oxidase 1.4.3.2 0.670
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.670
3cox FADCholesterol oxidase 1.1.3.6 0.670
2igo FADPyranose 2-oxidase / 0.669
4bjz FADProbable salicylate monooxygenase / 0.669
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.669
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.668
3cnt FADPolyamine oxidase FMS1 / 0.668
3f8d FADNADH oxidase/thioredoxin reductase / 0.668
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.668
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.667
1ng4 FADGlycine oxidase 1.4.3.19 0.667
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.667
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.667
4jn9 FADDepH / 0.667
4la1 FADThioredoxin glutathione reductase / 0.667
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.666
3lsm SFDPyranose 2-oxidase / 0.666
3hdy FADUDP-galactopyranose mutase / 0.665
3lsh FADPyranose 2-oxidase / 0.665
4at0 FADPossible succinate dehydrogenase / 0.665
1b4v FADCholesterol oxidase 1.1.3.6 0.664
2gj3 FADNitrogen fixation regulatory protein 2.7.13.3 0.664
3fmw FADOxygenase / 0.664
3lov FADProtoporphyrinogen oxidase / 0.664
4bk2 FADProbable salicylate monooxygenase / 0.664
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.663
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.663
4u2t FADCholesterol oxidase 1.1.3.6 0.663
2pr5 FMNBlue-light photoreceptor / 0.662
4cnj FADL-amino acid oxidase / 0.662
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.661
2vvl FADMonoamine oxidase N 1.4.3.4 0.661
4ysh FADGlycine oxidase / 0.661
3t37 FADPyridoxine 4-oxidase / 0.660
4j34 FADKynurenine 3-monooxygenase / 0.660
1gxf FADTrypanothione reductase 1.8.1.12 0.659
1k0j FADp-hydroxybenzoate hydroxylase / 0.659
2ba9 FADPutative aminooxidase / 0.659
2yg7 FADPutrescine oxidase / 0.659
3lsi FADPyranose 2-oxidase / 0.659
3rp8 FADFAD-dependent urate hydroxylase / 0.659
3gyj FADCholesterol oxidase 1.1.3.6 0.658
4fk1 FADPutative thioredoxin reductase / 0.658
1ryi FADGlycine oxidase 1.4.3.19 0.657
4x4j FADPutative oxygenase / 0.657
1rx0 FADIsobutyryl-CoA dehydrogenase, mitochondrial 1.3.99 0.656
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.656
3k4n FADPyranose 2-oxidase / 0.656
2z6d FMNPhototropin-2 2.7.11.1 0.655
4jq9 FADDihydrolipoyl dehydrogenase / 0.655
1cf3 FADGlucose oxidase 1.1.3.4 0.654
2q0k FADThioredoxin reductase 1.8.1.9 0.654
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.654
1b8s FADCholesterol oxidase 1.1.3.6 0.652
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.652
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.652
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.652
4ntc FADThioredoxin reductase gliT / 0.652
4opl FDAConserved Archaeal protein / 0.652
5hxw FADL-amino acid deaminase / 0.652
1h83 FADPolyamine oxidase 1.5.3.14 0.651
2yg6 FADPutrescine oxidase / 0.651
4fwe FADLysine-specific histone demethylase 1B 1 0.651
4j36 FADKynurenine 3-monooxygenase / 0.651
5dju FMNNPH1-2 / 0.651
3mj4 FADUDP-galactopyranose mutase / 0.650
3uka FADUDP-galactopyranose mutase / 0.650
5dbj FADFADH2-dependent halogenase PltA / 0.650