sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 1.249 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 1.056 | |
| 3sx2 | NAD | Uncharacterized protein | / | 1.017 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 1.003 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 1.001 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 1.001 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.992 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.970 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.968 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.956 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.949 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.936 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.932 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.932 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.930 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.929 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.925 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.921 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.915 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.915 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.909 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.908 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.907 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.904 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.902 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.900 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.898 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.887 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.881 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.877 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.877 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.876 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.873 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.870 | |
| 4kwh | NAP | Reductase homolog | / | 0.869 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.867 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.867 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.863 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.862 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.861 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.860 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.859 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.858 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.857 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.850 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.847 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.846 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.845 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.845 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.844 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.843 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.842 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.841 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.840 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.838 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.838 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.838 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.835 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.829 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.828 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.825 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.825 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.824 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.824 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.823 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.822 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.818 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.817 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.816 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.815 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.815 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.813 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.812 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.809 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.807 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.806 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.804 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.803 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.800 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.799 | |
| 4qec | NAP | ElxO | / | 0.798 | |
| 1iy8 | NAD | Levodione reductase | / | 0.797 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.795 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.795 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.793 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.793 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.792 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.792 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.792 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.787 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.786 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.782 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.781 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.778 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.776 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.775 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.775 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.772 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.772 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.771 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.769 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.768 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.768 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.767 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.767 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.766 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.765 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.765 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.764 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.764 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.763 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.762 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.759 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.758 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.756 | |
| 4u7w | NDP | MxaA | / | 0.756 | |
| 1sny | NAP | LD36273p | / | 0.755 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.755 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.754 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.751 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.750 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.749 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.748 | |
| 3uce | NDP | Dehydrogenase | / | 0.748 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.746 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.745 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.744 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.744 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.743 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.743 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.743 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.743 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.742 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.742 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.740 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.739 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.739 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.737 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.737 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.737 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.736 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.736 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.735 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.734 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.733 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.733 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.732 | |
| 3bmo | NAP | Pteridine reductase | / | 0.732 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.731 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.731 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.731 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.729 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.726 | |
| 3mje | NDP | AmphB | / | 0.725 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.724 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.724 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.723 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.723 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.721 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.721 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.721 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.718 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.716 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.716 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.716 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.716 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.715 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.715 | |
| 4hxy | NDP | Plm1 | / | 0.713 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.712 | |
| 3sju | NDP | Keto reductase | / | 0.712 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.710 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.710 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.709 | |
| 4y9d | NAI | C alpha-dehydrogenase | / | 0.709 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.708 | |
| 5d2e | NAP | MlnE | / | 0.707 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.706 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.705 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.705 | |
| 2dt5 | NAD | Redox-sensing transcriptional repressor Rex | / | 0.704 | |
| 2hmv | ADP | Ktr system potassium uptake protein A | / | 0.704 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.704 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.703 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.703 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.701 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.700 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.700 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.700 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.700 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.699 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.699 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.698 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.698 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.696 | |
| 1jki | NAI | Inositol-3-phosphate synthase | 5.5.1.4 | 0.695 | |
| 3pef | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.694 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.694 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.693 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.693 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.693 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.692 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.691 | |
| 3oa2 | NAD | UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase | / | 0.691 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.691 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.691 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.690 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.688 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.687 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.687 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.687 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.687 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.687 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.687 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.686 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.686 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.685 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.685 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.685 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.685 | |
| 4qed | NAP | ElxO | / | 0.685 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.685 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.683 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.682 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.682 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.682 | |
| 4o29 | SAH | Protein-L-isoaspartate O-methyltransferase | / | 0.682 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.680 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.680 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.679 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.678 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.678 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.677 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.675 | |
| 3ec7 | NAD | Inositol 2-dehydrogenase | / | 0.675 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.674 | |
| 2c7q | SAH | Modification methylase HhaI | 2.1.1.37 | 0.674 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.674 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.674 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.674 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.673 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.673 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.672 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.672 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.671 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.671 | |
| 2nyu | SAM | rRNA methyltransferase 2, mitochondrial | / | 0.670 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.670 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.669 | |
| 1p1h | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.668 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.668 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.666 | |
| 1ahh | NAD | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.665 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.665 | |
| 7mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.665 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.663 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.663 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.663 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.661 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.661 | |
| 4clo | NAP | Pteridine reductase | / | 0.661 | |
| 2o06 | MTA | Spermidine synthase | 2.5.1.16 | 0.660 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.658 | |
| 4okn | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.657 | |
| 5a05 | NDP | Glucose-fructose oxidoreductase | / | 0.657 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.656 | |
| 3pqf | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.656 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.656 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.655 | |
| 3t7s | SAM | Uncharacterized protein | / | 0.655 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.654 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.654 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.653 | |
| 2yw9 | NAP | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.653 | |
| 1j5p | NAD | L-aspartate dehydrogenase | 1.4.1.21 | 0.652 | |
| 1uay | ADN | Oxidoreductase | / | 0.652 | |
| 1wzi | NDP | Malate dehydrogenase | / | 0.652 | |
| 2ep7 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.652 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.652 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.652 | |
| 1qan | SAH | rRNA adenine N-6-methyltransferase | 2.1.1.184 | 0.651 | |
| 2g82 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.651 | |
| 2ixb | NAD | Alpha-N-acetylgalactosaminidase | 3.2.1.49 | 0.651 | |
| 1o6z | NAD | Malate dehydrogenase | / | 0.650 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.650 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.650 |