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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g89 UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2g89 UMPThymidylate synthase / 0.920
2g8a UMPThymidylate synthase / 0.820
1tsy UMPThymidylate synthase / 0.815
2g86 UMPThymidylate synthase / 0.813
1bp6 UMPThymidylate synthase / 0.798
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.792
1tsv UMPThymidylate synthase / 0.787
1bp0 UMPThymidylate synthase / 0.782
1f28 UMPThymidylate synthase 2.1.1.45 0.772
1njd UMPThymidylate synthase / 0.769
2tdm UMPThymidylate synthase / 0.765
1tsx UMPThymidylate synthase / 0.757
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.744
1vzb UMPThymidylate synthase / 0.741
4dq1 UMPThymidylate synthase / 0.739
1bid UMPThymidylate synthase / 0.736
5by6 UMPThymidylate synthase / 0.733
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.732
1nja DCMThymidylate synthase / 0.729
2fto TMPThymidylate synthase / 0.727
1jmh UMPThymidylate synthase / 0.720
1jmf UMPThymidylate synthase / 0.717
1njc DCMThymidylate synthase / 0.716
4fox UMPThymidylate synthase ThyA / 0.712
1bpj UMPThymidylate synthase / 0.711
1njb UMPThymidylate synthase / 0.706
1nje DCMThymidylate synthase / 0.704
1jmi UMPThymidylate synthase / 0.702
4e5o UMPThymidylate synthase 2.1.1.45 0.702
2g8d UMPThymidylate synthase / 0.700
3bgx TMPThymidylate synthase / 0.694
2tsr UMPThymidylate synthase 2.1.1.45 0.692
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.692
4isk UMPThymidylate synthase / 0.691
1jmg UMPThymidylate synthase / 0.682
4irr UMPThymidylate synthase / 0.679
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.678
1thy UMPThymidylate synthase / 0.674
4eb4 UMPThymidylate synthase 2.1.1.45 0.671
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.660
1ddu DDUThymidylate synthase / 0.660
3qj7 UMPThymidylate synthase ThyA / 0.657
1tys TMPThymidylate synthase / 0.655