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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2g1m 4HG Egl nine homolog 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2g1m 4HGEgl nine homolog 1 / 0.889
4bqy FNTEgl nine homolog 1 / 0.838
4bqw QNMEgl nine homolog 1 / 0.754
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.740
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.702
1ohj COPDihydrofolate reductase 1.5.1.3 0.670
1qmf KEFPenicillin-binding protein 2x / 0.670
2dhf DZFDihydrofolate reductase 1.5.1.3 0.667
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.667
4ie0 PD2Alpha-ketoglutarate-dependent dioxygenase FTO / 0.664
4koy CSCUncharacterized protein / 0.663
1hfp MOTDihydrofolate reductase 1.5.1.3 0.662
3td8 D2RDihydrofolate reductase 1.5.1.3 0.660
1dhf FOLDihydrofolate reductase 1.5.1.3 0.657
1jom FFODihydrofolate reductase 1.5.1.3 0.657
4wxf PLGSerine hydroxymethyltransferase / 0.655
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.654
2r4t ADPGlycogen synthase 2.4.1.21 0.654
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.653
1dyj DDFDihydrofolate reductase 1.5.1.3 0.650
4m6l 21VDihydrofolate reductase 1.5.1.3 0.650