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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fzi DH3 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fzi DH3Dihydrofolate reductase 1.5.1.3 1.053
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.888
3td8 D2RDihydrofolate reductase 1.5.1.3 0.812
1e26 GPBDihydrofolate reductase 1.5.1.3 0.762
1dls MTXDihydrofolate reductase 1.5.1.3 0.749
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 0.742
2drc MTXDihydrofolate reductase 1.5.1.3 0.736
4m6l 21VDihydrofolate reductase 1.5.1.3 0.727
3dau MTXDihydrofolate reductase 1.5.1.3 0.719
4p68 MTXDihydrofolate reductase / 0.716
2dhf DZFDihydrofolate reductase 1.5.1.3 0.713
1hfp MOTDihydrofolate reductase 1.5.1.3 0.710
2zza FOLDihydrofolate reductase / 0.710
4i13 FOLDihydrofolate reductase 1.5.1.3 0.706
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.705
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.698
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.692
4i1n FOLDihydrofolate reductase 1.5.1.3 0.692
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.685
4dfr MTXDihydrofolate reductase 1.5.1.3 0.684
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.684
1u70 MTXDihydrofolate reductase 1.5.1.3 0.680
2d0k FOLDihydrofolate reductase 1.5.1.3 0.676
1fnd A2PFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.674
5hi6 MTXDihydrofolate reductase / 0.673
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.669
1hfr MOTDihydrofolate reductase 1.5.1.3 0.668
1lud TRRDihydrofolate reductase 1.5.1.3 0.666
1obn ASVIsopenicillin N synthase 1.21.3.1 0.666
4keb FOLDihydrofolate reductase 1.5.1.3 0.656
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.653
1drf FOLDihydrofolate reductase 1.5.1.3 0.652
2w3m FOLDihydrofolate reductase 1.5.1.3 0.652
1giq NAIIota toxin component Ia / 0.651
1x1a SAMC-20 methyltransferase / 0.651
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 0.651
4x5g FOLDihydrofolate reductase 1.5.1.3 0.651
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.650