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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fvl NAP Aldo-keto reductase family 1 member C4 1.1.1.225

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 1.343
4jtq NAPAldo-keto reductase family 1 member C2 / 1.206
4l1x NAPAldo-keto reductase family 1 member C2 / 1.189
1s1r NAPAldo-keto reductase family 1 member C3 / 1.143
4dz5 NAPAldo-keto reductase family 1 member C3 / 1.137
4xo7 NAPAldo-keto reductase family 1 member C2 / 1.107
1s1p NAPAldo-keto reductase family 1 member C3 / 1.077
4jq3 NAPAldo-keto reductase family 1 member C2 / 1.069
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.052
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.030
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.016
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 1.004
2acu NAPAldose reductase 1.1.1.21 0.992
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.989
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 0.986
2hdj NDPAldo-keto reductase family 1 member C2 / 0.983
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.965
1x98 NAPAldose reductase 1.1.1.21 0.961
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.956
2pev NDPAldose reductase 1.1.1.21 0.952
2pf8 NDPAldose reductase 1.1.1.21 0.943
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.930
1z8a NAPAldose reductase 1.1.1.21 0.930
2j8t NAPAldose reductase 1.1.1.21 0.925
2acs NAPAldose reductase 1.1.1.21 0.923
1az2 NAPAldose reductase 1.1.1.21 0.921
2vdg NDPAldose reductase 1.1.1.21 0.921
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.916
1x96 NAPAldose reductase 1.1.1.21 0.913
2bgs NDPAldose reductase 1.1.1.21 0.913
3q65 NAPAldose reductase 1.1.1.21 0.905
4pmj NAPPutative oxidoreductase / 0.900
3q67 NAPAldose reductase 1.1.1.21 0.894
1ads NAPAldose reductase 1.1.1.21 0.891
5c7h NDPPutative oxidoreductase / 0.891
1ah4 NAPAldose reductase 1.1.1.21 0.890
3v36 NAPAldose reductase 1.1.1.21 0.880
2iq0 NAPAldose reductase 1.1.1.21 0.878
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.876
2acq NAPAldose reductase 1.1.1.21 0.875
4g5d NDPProstaglandin F synthase 1.1.1.188 0.858
3h7r NAPAldo-keto reductase family 4 member C8 / 0.852
1zgd NAPChalcone reductase / 0.835
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.831
2pfh NDPAldose reductase 1.1.1.21 0.826
3qkz NAPAldose reductase-related protein 1 1.1.1.21 0.812
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 0.811
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.804
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.799
3wcz NAPAldo-keto reductase AKR2E4 / 0.798
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.795
1ef3 NAPAldose reductase 1.1.1.21 0.789
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.781
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.781
3ln3 NADAldo-keto reductase family 1 member C13 / 0.765
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 0.761
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.751
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.750
1c9w NAPAldose reductase-related protein 2 / 0.737
1pz1 NAPGeneral stress protein 69 / 0.736
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.733
1lqa NDPProtein tas / 0.719
1og6 NAPOxidoreductase YdhF 1 0.716
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.709
2r9r NAPVoltage-gated potassium channel subunit beta-2 / 0.700
4jta NAPVoltage-gated potassium channel subunit beta-2 / 0.695
4aub NAPL-glyceraldehyde 3-phosphate reductase 1.1.1 0.694
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.689
3lut NAPVoltage-gated potassium channel subunit beta-2 / 0.689
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.686
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.674
2c91 NAPAflatoxin B1 aldehyde reductase member 2 / 0.669
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.668
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.666
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.660
2wzm NA7Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346 / 0.660
1a9c GTPGTP cyclohydrolase 1 3.5.4.16 0.658
1lwi NAP3-alpha-hydroxysteroid dehydrogenase 1.1.1.50 0.656
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.656
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.654