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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fav APR Nonstructural polyprotein pp1a

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fav APRNonstructural polyprotein pp1a / 1.265
3ewr APRReplicase polyprotein 1a 3.4.22 0.884
2bfq AR6[Protein ADP-ribosylglutamate] hydrolase AF_1521 3.2.2 0.883
5fsy AR6Uncharacterized protein / 0.880
3gqo APRNon-structural polyprotein / 0.879
3sig AR6Uncharacterized protein / 0.764
5cb5 APRO-acetyl-ADP-ribose deacetylase / 0.745
3iid APRCore histone macro-H2A.1 / 0.742
4j5r A1RO-acetyl-ADP-ribose deacetylase 1 3.5.1 0.731
4b1h AR6Poly(ADP-ribose) glycohydrolase 3.2.1.143 0.685
2wvj TTPThymidine kinase, cytosolic 2.7.1.21 0.665
4kxl 6C62'-deoxynucleoside 5'-phosphate N-hydrolase 1 / 0.662
5cb3 APRO-acetyl-ADP-ribose deacetylase / 0.660
3uel A1RPoly(ADP-ribose) glycohydrolase 3.2.1.143 0.656
2xjc 5GPCytosolic purine 5'-nucleotidase 3.1.3.5 0.653
2bfr ADP[Protein ADP-ribosylglutamate] hydrolase AF_1521 3.2.2 0.650