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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2exm ZIP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2exm ZIPCyclin-dependent kinase 2 2.7.11.22 0.806
3b2t M33Fibroblast growth factor receptor 2 / 0.677
1h0v UN4Cyclin-dependent kinase 2 2.7.11.22 0.676
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.657
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.654
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.650