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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2eva ADN Mitogen-activated protein kinase kinase kinase 7 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.811
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.702
3b2t M33Fibroblast growth factor receptor 2 / 0.693
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.691
2wqe ADPAurora kinase A 2.7.11.1 0.684
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.678
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.676
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.675
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.675
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.674
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.674
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.674
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.670
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.670
3cok ANPSerine/threonine-protein kinase PLK4 2.7.11.21 0.670
3uim ANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 2.7.10.1 0.669
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.668
4dca ADPAminoglycoside phosphotransferase / 0.668
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.665
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.664
4ix6 ADPUncharacterized protein / 0.662
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.661
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.659
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.659
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.659
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.659
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.657
2vgo AD5Aurora kinase B-A 2.7.11.1 0.657
4c3r ACPAurora kinase A 2.7.11.1 0.657
4j97 ACPFibroblast growth factor receptor 2 / 0.657
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.657
5eg3 ACPFibroblast growth factor receptor 2 / 0.656
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.654
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.654
5dr2 ATPAurora kinase A 2.7.11.1 0.654
1ir3 ANPInsulin receptor 2.7.10.1 0.653
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.653
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.652
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.652
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.652
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.652
3zc6 VFCTyrosine-protein kinase JAK3 2.7.10.2 0.651
4j95 ACPFibroblast growth factor receptor 2 / 0.651
4ogr ADNCyclin-dependent kinase 9 2.7.11.22 0.651
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.650
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.650
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.650
5l8j ADPAurora kinase A 2.7.11.1 0.650