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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ev9 NAP Shikimate dehydrogenase (NADP(+))

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ev9 NAPShikimate dehydrogenase (NADP(+)) / 1.177
2cy0 NAPShikimate dehydrogenase (NADP(+)) / 0.955
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.878
2jkv NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.791
2hk9 NAPShikimate dehydrogenase (NADP(+)) / 0.751
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.708
1nvt NAPShikimate dehydrogenase (NADP(+)) / 0.700
3toz NADShikimate dehydrogenase (NADP(+)) / 0.678
3t4e NADQuinate/shikimate dehydrogenase / 0.677
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.676
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.667
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.660
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.660
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.660
5a9s NAPPutative dehydrogenase / 0.660
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.659
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.657
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.655
4y1b NAPAntE / 0.655
1hdo NAPFlavin reductase (NADPH) / 0.653
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.653
2iyp A2P6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.651
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.650
4y0k NAPAntE / 0.650