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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ek4 SAH Diphthine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ek4 SAHDiphthine synthase / 1.119
2eh4 SAHDiphthine synthase / 1.115
2pcg SAHDiphthine synthase / 1.115
2e8s SAHDiphthine synthase / 1.114
2en5 SAHDiphthine synthase / 1.114
2pb5 SAHDiphthine synthase / 1.114
2e8r SAHDiphthine synthase / 1.113
2eh5 SAHDiphthine synthase / 1.113
2emr SAHDiphthine synthase / 1.113
2eka SAHDiphthine synthase / 1.112
2el3 SAHDiphthine synthase / 1.111
2pca SAHDiphthine synthase / 1.098
2ek7 SAHDiphthine synthase / 1.096
2dv3 SAHDiphthine synthase / 1.095
2dxx SAHDiphthine synthase / 1.095
2e4n SAHDiphthine synthase / 1.095
2ed5 SAHDiphthine synthase / 1.095
2ele SAHDiphthine synthase / 1.095
2p9d SAHDiphthine synthase / 1.095
2pb6 SAHDiphthine synthase / 1.095
2pcm SAHDiphthine synthase / 1.095
2p5f SAHDiphthine synthase / 1.094
2ek2 SAHDiphthine synthase / 1.093
2eni SAHDiphthine synthase / 1.093
2p6l SAHDiphthine synthase / 1.093
2p6k SAHDiphthine synthase / 1.092
2ek3 SAHDiphthine synthase / 1.091
2pck SAHDiphthine synthase / 1.091
2owg SAHDiphthine synthase / 1.088
2p6d SAHDiphthine synthase / 1.087
2eld SAHDiphthine synthase / 1.080
2dv5 SAHDiphthine synthase / 1.077
2egs SAHDiphthine synthase / 1.077
2eh2 SAHDiphthine synthase / 1.077
2pch SAHDiphthine synthase / 1.077
2dxw SAHDiphthine synthase / 1.076
2e08 SAHDiphthine synthase / 1.075
2e8h SAHDiphthine synthase / 1.075
2el0 SAHDiphthine synthase / 1.075
2owk SAHDiphthine synthase / 1.075
2pb4 SAHDiphthine synthase / 1.075
2e17 SAHDiphthine synthase / 1.074
2p6i SAHDiphthine synthase / 1.074
1wng SAHDiphthine synthase / 1.073
2huv SAHDiphthine synthase / 1.073
2eeq SAHDiphthine synthase / 1.072
2ejk SAHDiphthine synthase / 1.059
2huq SAHDiphthine synthase / 1.059
2dxv SAHDiphthine synthase / 1.058
2e07 SAHDiphthine synthase / 1.058
2e7r SAHDiphthine synthase / 1.058
2egb SAHDiphthine synthase / 1.058
2ehl SAHDiphthine synthase / 1.058
2ejj SAHDiphthine synthase / 1.058
2z6r SAHDiphthine synthase / 1.058
2dsh SAHDiphthine synthase / 1.057
2egl SAHDiphthine synthase / 1.057
2dsg SAHDiphthine synthase / 1.056
2e15 SAHDiphthine synthase / 1.056
2dek SAHDiphthine synthase / 1.055
2e16 SAHDiphthine synthase / 1.055
2owu SAHDiphthine synthase / 1.053
2e8q SAHDiphthine synthase / 1.045
2p2x SAHDiphthine synthase / 1.045
2dsi SAHDiphthine synthase / 1.042
2dv7 SAHDiphthine synthase / 1.042
2emu SAHDiphthine synthase / 1.042
2p5c SAHDiphthine synthase / 1.041
2dv4 SAHDiphthine synthase / 1.038
2owv SAHDiphthine synthase / 1.035
2pci SAHDiphthine synthase / 1.026
2hut SAHDiphthine synthase / 1.023
1vce SAHDiphthine synthase / 1.022
2hux SAHDiphthine synthase / 0.950
2hr8 SAHDiphthine synthase / 0.918
2ejz SAHDiphthine synthase / 0.829
2owf SAHDiphthine synthase / 0.731
2ed3 SAHDiphthine synthase / 0.705
2e0n SAHPrecorrin-2 C20-methyltransferase / 0.689
2ha8 SAHProbable methyltransferase TARBP1 / 0.685
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.678
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.676
3s3t ATPUniversal stress protein / 0.668
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.663
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.662
4ypa SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.662
3nut SAHPrecorrin-3 methylase / 0.661
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.659
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.659
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.657
1cbf SAHCobalt-precorrin-4 C(11)-methyltransferase 2.1.1.271 0.655
1id0 ANPSensor protein PhoQ 2.7.13.3 0.655
1kp3 ATPArgininosuccinate synthase 6.3.4.5 0.654
4bw9 ANPPyrrolysine--tRNA ligase / 0.653
4rrb A3TProbable threonine--tRNA ligase 2 6.1.1.3 0.653
4rrl A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.653
2ydo ADNAdenosine receptor A2a / 0.652
4rr6 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.652
1kp2 ATPArgininosuccinate synthase 6.3.4.5 0.651
4rr7 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.651
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650