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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2egs SAH Diphthine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2egs SAHDiphthine synthase / 1.102
2dv3 SAHDiphthine synthase / 1.097
1wng SAHDiphthine synthase / 1.095
2dv5 SAHDiphthine synthase / 1.093
2dxv SAHDiphthine synthase / 1.080
2ed5 SAHDiphthine synthase / 1.079
2dsh SAHDiphthine synthase / 1.078
2dv7 SAHDiphthine synthase / 1.078
2e08 SAHDiphthine synthase / 1.078
2eeq SAHDiphthine synthase / 1.078
2el0 SAHDiphthine synthase / 1.078
2huv SAHDiphthine synthase / 1.078
2dsi SAHDiphthine synthase / 1.077
2e8s SAHDiphthine synthase / 1.077
2eh4 SAHDiphthine synthase / 1.077
2ejj SAHDiphthine synthase / 1.077
2ek4 SAHDiphthine synthase / 1.077
2en5 SAHDiphthine synthase / 1.077
2p5f SAHDiphthine synthase / 1.077
2pca SAHDiphthine synthase / 1.077
2pcg SAHDiphthine synthase / 1.077
2eld SAHDiphthine synthase / 1.076
2emr SAHDiphthine synthase / 1.076
2pb5 SAHDiphthine synthase / 1.076
2e16 SAHDiphthine synthase / 1.075
2e8r SAHDiphthine synthase / 1.075
2eh5 SAHDiphthine synthase / 1.075
2ek2 SAHDiphthine synthase / 1.075
2eka SAHDiphthine synthase / 1.075
2el3 SAHDiphthine synthase / 1.075
1vce SAHDiphthine synthase / 1.073
2pb6 SAHDiphthine synthase / 1.073
2p2x SAHDiphthine synthase / 1.070
2p6d SAHDiphthine synthase / 1.065
2dsg SAHDiphthine synthase / 1.064
2egb SAHDiphthine synthase / 1.063
2owk SAHDiphthine synthase / 1.063
2e17 SAHDiphthine synthase / 1.062
2e07 SAHDiphthine synthase / 1.061
2e7r SAHDiphthine synthase / 1.061
2egl SAHDiphthine synthase / 1.061
2pch SAHDiphthine synthase / 1.061
2dxw SAHDiphthine synthase / 1.060
2dxx SAHDiphthine synthase / 1.060
2ehl SAHDiphthine synthase / 1.060
2owv SAHDiphthine synthase / 1.060
2p6i SAHDiphthine synthase / 1.060
2e15 SAHDiphthine synthase / 1.059
2eh2 SAHDiphthine synthase / 1.059
2z6r SAHDiphthine synthase / 1.059
2e4n SAHDiphthine synthase / 1.058
2ek7 SAHDiphthine synthase / 1.058
2ele SAHDiphthine synthase / 1.058
2p9d SAHDiphthine synthase / 1.058
2ejk SAHDiphthine synthase / 1.057
2eni SAHDiphthine synthase / 1.057
2dek SAHDiphthine synthase / 1.056
2e8h SAHDiphthine synthase / 1.056
2huq SAHDiphthine synthase / 1.056
2owg SAHDiphthine synthase / 1.056
2p6k SAHDiphthine synthase / 1.056
2p6l SAHDiphthine synthase / 1.056
2pcm SAHDiphthine synthase / 1.056
2dv4 SAHDiphthine synthase / 1.055
2owu SAHDiphthine synthase / 1.055
2pck SAHDiphthine synthase / 1.054
2ek3 SAHDiphthine synthase / 1.053
2p5c SAHDiphthine synthase / 1.052
2pb4 SAHDiphthine synthase / 1.052
2e8q SAHDiphthine synthase / 1.046
2hut SAHDiphthine synthase / 1.044
2pci SAHDiphthine synthase / 1.036
2emu SAHDiphthine synthase / 1.035
2hux SAHDiphthine synthase / 0.952
2hr8 SAHDiphthine synthase / 0.885
2ejz SAHDiphthine synthase / 0.845
2owf SAHDiphthine synthase / 0.778
2ed3 SAHDiphthine synthase / 0.705
2zvc SAHPrecorrin-3 C17-methyltransferase / 0.697
1cbf SAHCobalt-precorrin-4 C(11)-methyltransferase 2.1.1.271 0.694
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.686
3s3t ATPUniversal stress protein / 0.682
4x3l MTARNA 2'-O ribose methyltransferase / 0.682
1s4d SAHUroporphyrinogen-III C-methyltransferase 2.1.1.107 0.680
2ha8 SAHProbable methyltransferase TARBP1 / 0.673
1j21 ATPArgininosuccinate synthase / 0.671
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.664
1kor ANPArgininosuccinate synthase / 0.659
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.658
4ypa SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.658
3n4k SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.656
2egw SAHRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.655
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.655
1id0 ANPSensor protein PhoQ 2.7.13.3 0.654
2bb3 SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE) / 0.654
2zio AYBPyrrolysine--tRNA ligase / 0.652
4rrb A3TProbable threonine--tRNA ligase 2 6.1.1.3 0.652
4rrl A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.652
2qbu SAHPrecorrin-2 methyltransferase / 0.651