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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e9u A25 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2e9u A25Serine/threonine-protein kinase Chk1 2.7.11.1 0.880
4ft5 H2KSerine/threonine-protein kinase Chk1 2.7.11.1 0.746
4e5i 0N9Polymerase acidic protein / 0.744
4ft3 H1KSerine/threonine-protein kinase Chk1 2.7.11.1 0.744
4fta H5KSerine/threonine-protein kinase Chk1 2.7.11.1 0.724
2e9v 85ASerine/threonine-protein kinase Chk1 2.7.11.1 0.717
2yer TQ1Serine/threonine-protein kinase Chk1 2.7.11.1 0.680
2yex YEXSerine/threonine-protein kinase Chk1 2.7.11.1 0.676
2ym8 YM8Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
4ft7 H3KSerine/threonine-protein kinase Chk1 2.7.11.1 0.669
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.667
4ftj H8KSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4ftc H6KSerine/threonine-protein kinase Chk1 2.7.11.1 0.659
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.653
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.652