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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e95 B75 Geranylgeranyl pyrophosphate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2e95 B75Geranylgeranyl pyrophosphate synthase / 1.403
2e91 ZOLGeranylgeranyl pyrophosphate synthase / 0.832
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.821
2f94 BFQFarnesyl pyrophosphate synthase 2.5.1.10 0.810
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.808
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.790
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.780
3ldw ZOLFarnesyl pyrophosphate synthase, putative / 0.778
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.763
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.755
2zev B71Geranylgeranyl pyrophosphate synthase / 0.747
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.745
4q23 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.741
2z4w 749Geranylgeranyl pyrophosphate synthase / 0.734
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.720
4dxj 0M9Farnesyl pyrophosphate synthase / 0.720
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.711
1yq7 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.691
2o1o RISPutative farnesyl pyrophosphate synthase / 0.686
3krf DSTGeranyl diphosphate synthase large subunit / 0.672
5erm 210Fusicoccadiene synthase 4.2.3.43 0.670
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.663