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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e77 FMN Lactate oxidase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2e77 FMNLactate oxidase / 1.320
4rje FNRLactate oxidase / 1.252
4yl2 FMNLactate oxidase / 1.204
2nli FMNLactate oxidase / 1.170
2zfa FMNLactate oxidase / 1.117
5ebu FMNLactate oxidase / 1.093
2du2 FMNLactate oxidase / 1.087
2j6x FMNLactate oxidase / 0.930
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.869
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.866
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.840
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.826
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.792
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.779
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.771
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.768
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.768
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.762
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.759
4utl FNRXenobiotic reductase / 0.759
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.756
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.756
4e2d FMNDehydrogenase / 0.755
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.753
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.751
3p74 FMNPentaerythritol tetranitrate reductase / 0.750
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.747
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.747
5cpm FNRNADH:flavin oxidoreductase / 0.747
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.746
4utm FNRXenobiotic reductase / 0.745
2h8x FMNXenA / 0.743
3l5l FMNXenobiotic reductase / 0.739
3p62 FMNPentaerythritol tetranitrate reductase / 0.735
4tmb FMNOld yellow enzyme / 0.735
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.732
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.732
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.729
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.725
3p8i FMNPentaerythritol tetranitrate reductase / 0.724
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.723
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.723
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.718
2cdu FADNADH oxidase / 0.716
4yco FMNtRNA-dihydrouridine(16) synthase / 0.714
3n14 FMNXenobiotic reductase / 0.712
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.711
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.710
3aty FMNProstaglandin F2a synthase / 0.708
3tjl FMNNADPH dehydrogenase / 0.706
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.705
1vhn FMNtRNA-dihydrouridine synthase / 0.704
3f03 FMNPentaerythritol tetranitrate reductase / 0.704
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.700
1gwj FMNMorphinone reductase / 0.699
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.699
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.697
1z44 FMNNADPH dehydrogenase / 0.696
3l67 FMNXenobiotic reductase / 0.696
3p8j FMNPentaerythritol tetranitrate reductase / 0.695
3p67 FMNPentaerythritol tetranitrate reductase / 0.694
3p84 FMNPentaerythritol tetranitrate reductase / 0.694
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.694
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.692
3atz FMNProstaglandin F2a synthase / 0.691
3p82 FMNPentaerythritol tetranitrate reductase / 0.691
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.691
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.691
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.690
4df2 FMNNADPH dehydrogenase / 0.689
4qai FMNNADPH dehydrogenase / 0.689
4uth FMNXenobiotic reductase / 0.687
4e2b FMNDehydrogenase / 0.684
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.683
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.681
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.680
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.679
1z41 FMNNADPH dehydrogenase / 0.677
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.677
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.677
1h50 FMNPentaerythritol tetranitrate reductase / 0.676
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
4df4 0L3DNA polymerase I, thermostable 2.7.7.7 0.676
2zaf FADNitroalkane oxidase 1.7.3.1 0.675
2z6i FMN2-nitropropane dioxygenase / 0.674
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.673
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.673
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.671
4hut ATPCob(I)yrinic acid a,c-diamide adenosyltransferase 2.5.1.17 0.671
4jic FMNGTN Reductase / 0.671
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.669
2dvl FADAcyl-CoA dehydrogenase / 0.669
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.666
4tmc FMNOld yellow enzyme / 0.664
3t0i SAHPutative methyltransferase / 0.662
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.661
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.661
1h63 FMNPentaerythritol tetranitrate reductase / 0.660
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
1ege FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.659
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.659
3ept FDAPutative FAD-monooxygenase / 0.658
4iv6 FDAIsovaleryl-CoA dehydrogenase / 0.657
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.655
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.655
3hf3 FMNChromate reductase / 0.655
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.655
1u3d FADCryptochrome-1 / 0.654
3esz FMNFlavodoxin / 0.654
4la1 FADThioredoxin glutathione reductase / 0.654
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.653
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.652
4mkh AP5Adenylate kinase / 0.652
4ttc FMNIodotyrosine deiodinase 1 / 0.652
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.650