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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e15 SAH Diphthine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2e15 SAHDiphthine synthase / 1.104
2e7r SAHDiphthine synthase / 1.085
2e07 SAHDiphthine synthase / 1.084
2dxw SAHDiphthine synthase / 1.083
2egb SAHDiphthine synthase / 1.083
2ehl SAHDiphthine synthase / 1.083
2dsg SAHDiphthine synthase / 1.082
2e17 SAHDiphthine synthase / 1.082
2egl SAHDiphthine synthase / 1.082
2dsh SAHDiphthine synthase / 1.081
2e16 SAHDiphthine synthase / 1.081
2z6r SAHDiphthine synthase / 1.081
2p6k SAHDiphthine synthase / 1.079
2p6l SAHDiphthine synthase / 1.079
2dek SAHDiphthine synthase / 1.077
2el0 SAHDiphthine synthase / 1.076
2dv5 SAHDiphthine synthase / 1.074
2e8r SAHDiphthine synthase / 1.074
2eeq SAHDiphthine synthase / 1.073
2pb6 SAHDiphthine synthase / 1.073
2owu SAHDiphthine synthase / 1.072
2dxv SAHDiphthine synthase / 1.065
2dxx SAHDiphthine synthase / 1.064
2e08 SAHDiphthine synthase / 1.063
2dv7 SAHDiphthine synthase / 1.062
2e4n SAHDiphthine synthase / 1.062
2eh2 SAHDiphthine synthase / 1.062
2owk SAHDiphthine synthase / 1.062
2pck SAHDiphthine synthase / 1.062
2ek7 SAHDiphthine synthase / 1.061
2dv4 SAHDiphthine synthase / 1.060
2ejj SAHDiphthine synthase / 1.060
2ele SAHDiphthine synthase / 1.060
2eni SAHDiphthine synthase / 1.060
2p9d SAHDiphthine synthase / 1.060
2ed5 SAHDiphthine synthase / 1.059
2egs SAHDiphthine synthase / 1.059
2p6i SAHDiphthine synthase / 1.059
2dsi SAHDiphthine synthase / 1.058
2emu SAHDiphthine synthase / 1.058
2dv3 SAHDiphthine synthase / 1.057
2eh4 SAHDiphthine synthase / 1.057
2en5 SAHDiphthine synthase / 1.057
2hut SAHDiphthine synthase / 1.057
2pca SAHDiphthine synthase / 1.057
2e8s SAHDiphthine synthase / 1.056
2ejk SAHDiphthine synthase / 1.056
2ek3 SAHDiphthine synthase / 1.056
2ek4 SAHDiphthine synthase / 1.056
2eld SAHDiphthine synthase / 1.056
2emr SAHDiphthine synthase / 1.056
2p5f SAHDiphthine synthase / 1.056
2pb5 SAHDiphthine synthase / 1.056
2pcg SAHDiphthine synthase / 1.056
2ek2 SAHDiphthine synthase / 1.055
1wng SAHDiphthine synthase / 1.054
2eh5 SAHDiphthine synthase / 1.054
2eka SAHDiphthine synthase / 1.054
2el3 SAHDiphthine synthase / 1.054
2pcm SAHDiphthine synthase / 1.054
2huq SAHDiphthine synthase / 1.053
2huv SAHDiphthine synthase / 1.053
2p6d SAHDiphthine synthase / 1.053
2pb4 SAHDiphthine synthase / 1.053
2p5c SAHDiphthine synthase / 1.047
2pch SAHDiphthine synthase / 1.042
2e8h SAHDiphthine synthase / 1.035
2owv SAHDiphthine synthase / 1.035
2owg SAHDiphthine synthase / 1.034
1vce SAHDiphthine synthase / 1.033
2e8q SAHDiphthine synthase / 1.022
2pci SAHDiphthine synthase / 1.022
2p2x SAHDiphthine synthase / 0.999
2hux SAHDiphthine synthase / 0.926
2hr8 SAHDiphthine synthase / 0.870
2ejz SAHDiphthine synthase / 0.855
2owf SAHDiphthine synthase / 0.708
2ed3 SAHDiphthine synthase / 0.706
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.703
2zvc SAHPrecorrin-3 C17-methyltransferase / 0.697
2qbu SAHPrecorrin-2 methyltransferase / 0.696
2e0n SAHPrecorrin-2 C20-methyltransferase / 0.694
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.693
1cbf SAHCobalt-precorrin-4 C(11)-methyltransferase 2.1.1.271 0.690
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.687
2zvb SAHPrecorrin-3 C17-methyltransferase / 0.685
3s3t ATPUniversal stress protein / 0.684
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
2ha8 SAHProbable methyltransferase TARBP1 / 0.674
1s4d SAHUroporphyrinogen-III C-methyltransferase 2.1.1.107 0.672
1j21 ATPArgininosuccinate synthase / 0.671
1i44 ACPInsulin receptor 2.7.10.1 0.667
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.667
3n4k SAHtRNA (cytidine(34)-2'-O)-methyltransferase / 0.663
4cnf MTASpoU rRNA methylase / 0.663
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.663
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.661
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.661
1kor ANPArgininosuccinate synthase / 0.659
4cng SAHSpoU rRNA methylase / 0.659
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.655
4rrm A3TProbable threonine--tRNA ligase 2 6.1.1.3 0.655
4i0b CMPcAMP-activated global transcriptional regulator CRP / 0.654
1qrs ATPGlutamine--tRNA ligase 6.1.1.18 0.653
4rr8 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.652
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.651
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.650
2egw SAHRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.650