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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2e08 SAH Diphthine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2e08 SAHDiphthine synthase / 1.108
2dv5 SAHDiphthine synthase / 1.097
2dv3 SAHDiphthine synthase / 1.094
2owk SAHDiphthine synthase / 1.089
2p6i SAHDiphthine synthase / 1.086
2e16 SAHDiphthine synthase / 1.085
2e17 SAHDiphthine synthase / 1.085
2ek7 SAHDiphthine synthase / 1.084
2p9d SAHDiphthine synthase / 1.084
2dxv SAHDiphthine synthase / 1.083
2dxx SAHDiphthine synthase / 1.083
2eni SAHDiphthine synthase / 1.083
2dv4 SAHDiphthine synthase / 1.082
2dxw SAHDiphthine synthase / 1.082
2p6k SAHDiphthine synthase / 1.082
2p6l SAHDiphthine synthase / 1.082
2pcm SAHDiphthine synthase / 1.082
2dsh SAHDiphthine synthase / 1.081
2dv7 SAHDiphthine synthase / 1.081
2e4n SAHDiphthine synthase / 1.080
2ek3 SAHDiphthine synthase / 1.080
2pb5 SAHDiphthine synthase / 1.079
2egs SAHDiphthine synthase / 1.078
2ele SAHDiphthine synthase / 1.078
2e8r SAHDiphthine synthase / 1.077
2el3 SAHDiphthine synthase / 1.077
2pb6 SAHDiphthine synthase / 1.077
2pck SAHDiphthine synthase / 1.077
2en5 SAHDiphthine synthase / 1.076
2pcg SAHDiphthine synthase / 1.076
2e8s SAHDiphthine synthase / 1.075
2eh4 SAHDiphthine synthase / 1.075
2ek4 SAHDiphthine synthase / 1.075
2emr SAHDiphthine synthase / 1.075
1wng SAHDiphthine synthase / 1.074
2owv SAHDiphthine synthase / 1.074
2eka SAHDiphthine synthase / 1.073
2ejj SAHDiphthine synthase / 1.069
2dsg SAHDiphthine synthase / 1.066
2e07 SAHDiphthine synthase / 1.065
2e7r SAHDiphthine synthase / 1.065
2egl SAHDiphthine synthase / 1.065
2p5f SAHDiphthine synthase / 1.065
2egb SAHDiphthine synthase / 1.064
2ehl SAHDiphthine synthase / 1.064
2dsi SAHDiphthine synthase / 1.063
2e15 SAHDiphthine synthase / 1.063
2eeq SAHDiphthine synthase / 1.063
2eh5 SAHDiphthine synthase / 1.063
2dek SAHDiphthine synthase / 1.062
2eh2 SAHDiphthine synthase / 1.062
2emu SAHDiphthine synthase / 1.062
2z6r SAHDiphthine synthase / 1.062
2ejk SAHDiphthine synthase / 1.061
2owu SAHDiphthine synthase / 1.061
2ed5 SAHDiphthine synthase / 1.060
2owg SAHDiphthine synthase / 1.058
2p6d SAHDiphthine synthase / 1.058
2pca SAHDiphthine synthase / 1.058
2el0 SAHDiphthine synthase / 1.057
2eld SAHDiphthine synthase / 1.057
2huv SAHDiphthine synthase / 1.057
2pb4 SAHDiphthine synthase / 1.057
1vce SAHDiphthine synthase / 1.056
2ek2 SAHDiphthine synthase / 1.056
2huq SAHDiphthine synthase / 1.053
2p5c SAHDiphthine synthase / 1.052
2pch SAHDiphthine synthase / 1.041
2e8h SAHDiphthine synthase / 1.039
2e8q SAHDiphthine synthase / 1.034
2hut SAHDiphthine synthase / 1.031
2pci SAHDiphthine synthase / 1.023
2p2x SAHDiphthine synthase / 1.019
2hux SAHDiphthine synthase / 0.931
2hr8 SAHDiphthine synthase / 0.865
2ejz SAHDiphthine synthase / 0.848
2owf SAHDiphthine synthase / 0.753
4l2i FADElectron transfer flavoprotein alpha/beta-subunit / 0.726
2ed3 SAHDiphthine synthase / 0.706
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.703
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.689
1cbf SAHCobalt-precorrin-4 C(11)-methyltransferase 2.1.1.271 0.688
3s3t ATPUniversal stress protein / 0.688
2e0n SAHPrecorrin-2 C20-methyltransferase / 0.687
5a7y SAHtRNA (adenine(9)-N1)-methyltransferase 2.1.1.218 0.677
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.668
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.664
1s4d SAHUroporphyrinogen-III C-methyltransferase 2.1.1.107 0.662
2egw SAHRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.660
1kp3 ATPArgininosuccinate synthase 6.3.4.5 0.658
2qbu SAHPrecorrin-2 methyltransferase / 0.656
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.655
1mjh ATPUniversal stress protein MJ0577 / 0.654
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
1mbz IOTCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.650