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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dki FAD 3-hydroxybenzoate 4-monooxygenase 1.14.13.23

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 1.163
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.793
4jq9 FADDihydrolipoyl dehydrogenase / 0.781
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.764
3cgd FADCoenzyme A disulfide reductase / 0.744
2yqu FADDihydrolipoyl dehydrogenase / 0.740
4hb9 FADUncharacterized protein / 0.740
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.739
3cgc FADCoenzyme A disulfide reductase / 0.737
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.734
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.734
3q9t FAYUncharacterized protein / 0.733
1bzl FADTrypanothione reductase 1.8.1.12 0.730
2r0c FADPutative FAD-monooxygenase / 0.728
3cge FADCoenzyme A disulfide reductase / 0.724
2xdo FADTetX family tetracycline inactivation enzyme / 0.722
1pdh FASp-hydroxybenzoate hydroxylase / 0.721
2eq9 FADDihydrolipoyl dehydrogenase / 0.721
2rab FADGlutathione amide reductase / 0.721
4a99 FADTetX family tetracycline inactivation enzyme / 0.721
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.721
1n4u FAECholesterol oxidase 1.1.3.6 0.719
2r9z FADGlutathione amide reductase / 0.719
4tlz FADKtzI / 0.718
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.715
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.715
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.713
4guv FADTetX family tetracycline inactivation enzyme / 0.713
1mxt FAECholesterol oxidase 1.1.3.6 0.712
3gyi FADCholesterol oxidase 1.1.3.6 0.712
4b69 FADL-ornithine N(5)-monooxygenase / 0.712
4xwr FADCholesterol oxidase 1.1.3.6 0.712
5cku FADL-ornithine N(5)-monooxygenase / 0.712
2yg4 FADPutrescine oxidase / 0.711
3jsk AHZThiamine thiazole synthase / 0.710
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.710
4tm1 FDAKtzI / 0.710
2yg7 FADPutrescine oxidase / 0.708
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.708
1geu FADGlutathione reductase 1.8.1.7 0.707
2e1m FADL-glutamate oxidase / 0.706
3urh FADDihydrolipoyl dehydrogenase / 0.706
4tlx FDAKtzI / 0.706
1fec FADTrypanothione reductase 1.8.1.12 0.705
3cox FADCholesterol oxidase 1.1.3.6 0.705
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.705
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.704
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.703
3cgb FADCoenzyme A disulfide reductase / 0.703
4mo2 FDAUDP-galactopyranose mutase / 0.703
2tpr FADTrypanothione reductase 1.8.1.12 0.702
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.701
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.701
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.701
3ihg FADAklavinone 12-hydroxylase RdmE / 0.700
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
1get FADGlutathione reductase 1.8.1.7 0.699
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.699
4opl FDAConserved Archaeal protein / 0.699
2rgh FADAlpha-Glycerophosphate Oxidase / 0.697
3nlc FADUncharacterized protein / 0.697
4z24 FADPutative GMC-type oxidoreductase R135 1 0.697
1n4v FADCholesterol oxidase 1.1.3.6 0.696
3k30 ADPHistamine dehydrogenase / 0.696
4qi5 FADCellobiose dehydrogenase / 0.696
1ger FADGlutathione reductase 1.8.1.7 0.695
2q7v FADThioredoxin reductase / 0.695
2xvf FADPutative flavin-containing monooxygenase / 0.695
2yg5 FADPutrescine oxidase / 0.695
2cdu ADPNADH oxidase / 0.694
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.694
2hqm FADGlutathione reductase 1.8.1.7 0.694
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.693
4rsl FADFructosyl peptide oxidase / 0.692
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.692
2b9y FADPutative aminooxidase / 0.691
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.690
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.690
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.689
4qi4 FADCellobiose dehydrogenase / 0.689
1feb FADTrypanothione reductase 1.8.1.12 0.688
2eq6 FADDihydrolipoyl dehydrogenase / 0.688
4z26 FADPutative GMC-type oxidoreductase R135 1 0.688
5hsa FASAlcohol oxidase 1 1.1.3.13 0.688
2yg3 FADPutrescine oxidase / 0.687
4tm4 FDAKtzI / 0.687
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.686
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.685
2wba FADTrypanothione reductase 1.8.1.12 0.685
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.685
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.685
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
4nev FADTrypanothione reductase / 0.684
1b8s FADCholesterol oxidase 1.1.3.6 0.683
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.683
1qo8 FADFumarate reductase flavoprotein subunit / 0.683
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.682
4g6h NAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.682
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.682
2eq7 FADDihydrolipoyl dehydrogenase / 0.681
2gvc FADThiol-specific monooxygenase 1.14.13 0.681
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.681
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.680
3p9u FADTetX family tetracycline inactivation enzyme / 0.680
1ojt FADDihydrolipoyl dehydrogenase / 0.678
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.678
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.678
2xve FADPutative flavin-containing monooxygenase / 0.678
3qj4 FADRenalase / 0.678
4rek FADCholesterol oxidase 1.1.3.6 0.678
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.677
1f8r FADL-amino-acid oxidase 1.4.3.2 0.677
2bac FADPutative aminooxidase / 0.677
3ish FADThioredoxin reductase 1.8.1.9 0.677
3kkj FADRenalase / 0.677
2xvi FADPutative flavin-containing monooxygenase / 0.676
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
1cbo FADCholesterol oxidase 1.1.3.6 0.675
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.675
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.675
1cc2 FADCholesterol oxidase 1.1.3.6 0.674
3awi FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 1.5 0.674
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.674
3t37 FADPyridoxine 4-oxidase / 0.674
1d7l RFLp-hydroxybenzoate hydroxylase / 0.673
1gxf FADTrypanothione reductase 1.8.1.12 0.673
1zx9 FADMercuric reductase 1.16.1.1 0.673
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.673
4mok FADPyranose 2-oxidase / 0.673
4u2t FADCholesterol oxidase 1.1.3.6 0.673
3gyj FADCholesterol oxidase 1.1.3.6 0.672
2w0h FADTrypanothione reductase / 0.671
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.671
4mo2 FADUDP-galactopyranose mutase / 0.671
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.670
1n4w FADCholesterol oxidase 1.1.3.6 0.670
4x4j FADPutative oxygenase / 0.670
4xxg FADCholesterol oxidase 1.1.3.6 0.670
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.669
2xlp FADPutative flavin-containing monooxygenase / 0.669
3bi2 FADPolyamine oxidase FMS1 / 0.669
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.669
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.669
4u2l SFDCholesterol oxidase 1.1.3.6 0.669
1cf3 FADGlucose oxidase 1.1.3.4 0.668
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.668
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
3cnj FADCholesterol oxidase 1.1.3.6 0.668
4icy FADPgaE / 0.668
4u2s FDACholesterol oxidase 1.1.3.6 0.668
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.668
1ijh FADCholesterol oxidase 1.1.3.6 0.667
1zk7 FADMercuric reductase 1.16.1.1 0.667
2gew FADCholesterol oxidase 1.1.3.6 0.667
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
4b1b FADThioredoxin reductase 1.8.1.9 0.667
2ba9 FADPutative aminooxidase / 0.666
3b6d FAECholesterol oxidase 1.1.3.6 0.666
4b68 FADL-ornithine N(5)-monooxygenase / 0.666
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.666
2vvl FADMonoamine oxidase N 1.4.3.4 0.665
3ict FADCoenzyme A disulfide reductase / 0.665
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.665
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.665
4opc FDAConserved Archaeal protein / 0.665
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.664
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.663
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.663
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.663
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.662
3ics FADCoenzyme A disulfide reductase / 0.662
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.661
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.661
7mht SAHModification methylase HhaI 2.1.1.37 0.661
1f8s FADL-amino-acid oxidase 1.4.3.2 0.660
1gal FADGlucose oxidase 1.1.3.4 0.660
2vdv SAMtRNA (guanine-N(7)-)-methyltransferase / 0.660
1b4v FADCholesterol oxidase 1.1.3.6 0.659
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.659
4ap1 FADSteroid monooxygenase / 0.659
4dsg FADUncharacterized protein / 0.659
2qe6 SAMUncharacterized protein / 0.658
4b67 FADL-ornithine N(5)-monooxygenase / 0.658
4cnj FADL-amino acid oxidase / 0.658
4tm3 FADKtzI / 0.658
4yuz S4MSpermidine synthase, putative / 0.658
3axb FADPutative oxidoreductase / 0.657
3h5n ATPMccB protein / 0.657
3s5w FADL-ornithine N(5)-monooxygenase / 0.657
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.657
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.656
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.656
2o07 MTASpermidine synthase 2.5.1.16 0.656
3bi5 FADPolyamine oxidase FMS1 / 0.656
4b64 FADL-ornithine N(5)-monooxygenase / 0.656
1z6l FADPolyamine oxidase FMS1 / 0.655
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.655
4opd FDAConserved Archaeal protein / 0.655
1k0l FADp-hydroxybenzoate hydroxylase / 0.654
2xlr FADPutative flavin-containing monooxygenase / 0.654
3a25 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.654
3fbs FADOxidoreductase / 0.654
2qa1 FADPgaE / 0.653
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.653
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.653
2wow FADTrypanothione reductase / 0.652
3icr FADCoenzyme A disulfide reductase / 0.652
4k2x FADPolyketide oxygenase/hydroxylase / 0.652
1typ FADTrypanothione reductase 1.8.1.12 0.651
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.651
2np6 NEAModification methylase TaqI 2.1.1.72 0.651
4j2w FADKynurenine 3-monooxygenase / 0.651
1tdn FADL-amino-acid oxidase 1.4.3.2 0.650
2qa2 FADPolyketide oxygenase CabE / 0.650
2x3n FADProbable FAD-dependent monooxygenase / 0.650
2xyo FADTetX family tetracycline inactivation enzyme / 0.650