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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2djx FMN Dihydroorotate dehydrogenase (fumarate) 1.3.98.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.131
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.113
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.101
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.095
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.047
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.033
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 1.032
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 1.021
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 1.018
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.961
3oix FMNDihydroorotate dehydrogenase / 0.878
4utl FNRXenobiotic reductase / 0.862
4tmc FMNOld yellow enzyme / 0.860
4uth FMNXenobiotic reductase / 0.858
4utm FNRXenobiotic reductase / 0.858
3l67 FMNXenobiotic reductase / 0.847
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.845
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.845
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.843
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.841
4e2d FMNDehydrogenase / 0.837
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.836
4tmb FMNOld yellow enzyme / 0.834
2h8x FMNXenA / 0.833
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.833
3l5l FMNXenobiotic reductase / 0.830
1z48 FMNNADPH dehydrogenase / 0.829
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.823
4utk FNRXenobiotic reductase / 0.823
5cpm FNRNADH:flavin oxidoreductase / 0.823
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.820
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.817
3n14 FMNXenobiotic reductase / 0.816
3p84 FMNPentaerythritol tetranitrate reductase / 0.816
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.814
4e2b FMNDehydrogenase / 0.813
1h63 FMNPentaerythritol tetranitrate reductase / 0.811
1vyr FMNPentaerythritol tetranitrate reductase / 0.811
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.811
2abb FMNPentaerythritol tetranitrate reductase / 0.809
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.809
3hf3 FMNChromate reductase / 0.807
3p67 FMNPentaerythritol tetranitrate reductase / 0.807
3p62 FMNPentaerythritol tetranitrate reductase / 0.806
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.805
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.804
3p8j FMNPentaerythritol tetranitrate reductase / 0.804
3f03 FMNPentaerythritol tetranitrate reductase / 0.803
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.799
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.797
3atz FMNProstaglandin F2a synthase / 0.796
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.795
1h51 FMNPentaerythritol tetranitrate reductase / 0.794
3p8i FMNPentaerythritol tetranitrate reductase / 0.793
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.790
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.789
1h50 FMNPentaerythritol tetranitrate reductase / 0.788
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.787
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.786
1gwj FMNMorphinone reductase / 0.785
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.783
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.780
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.780
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.774
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.768
3n19 FNRXenobiotic reductase / 0.762
1z44 FMNNADPH dehydrogenase / 0.758
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.758
1z41 FMNNADPH dehydrogenase / 0.757
3gka FMNN-ethylmaleimide reductase / 0.754
3tjl FMNNADPH dehydrogenase / 0.747
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.747
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.737
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.736
2du2 FMNLactate oxidase / 0.736
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.735
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.734
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.733
2z6i FMN2-nitropropane dioxygenase / 0.732
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.728
5ebu FMNLactate oxidase / 0.725
4df2 FMNNADPH dehydrogenase / 0.718
3gr8 FMNNADPH dehydrogenase / 0.716
1vhn FMNtRNA-dihydrouridine synthase / 0.714
1ea0 FMNGlutamate synthase [NADPH] large chain 1.4.1.13 0.710
4cw5 FMNDfnA / 0.710
4m5p FMNNADPH dehydrogenase / 0.707
2nli FMNLactate oxidase / 0.705
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.703
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.701
4yl2 FMNLactate oxidase / 0.700
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.699
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.697
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.696
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.692
3qe2 FMNNADPH--cytochrome P450 reductase / 0.685
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.683
2ohj FMNType A flavoprotein FprA 1 0.682
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.682
2e77 FMNLactate oxidase / 0.679
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.679
4yco FMNtRNA-dihydrouridine(16) synthase / 0.679
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.667
2fcr FMNFlavodoxin / 0.663
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.663
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.663
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.661
4rje FNRLactate oxidase / 0.658
2g37 FADProline dehydrogenase / 0.657
2vyx FMNDodecin / 0.657
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.656
3w77 FMNFMN-dependent NADH-azoreductase / 0.653
4z38 FMNMlnA / 0.653